{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:20:40Z","timestamp":1792153240463,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T00:00:00Z","timestamp":1391817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Neuro\u2010beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">NBD<\/jats:styled-content>) is a rare complication of Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) but is still important due to its morbidity and mortality. In this study, we sought to identify the characteristics of <jats:styled-content style=\"fixed-case\">NBD<\/jats:styled-content> by examining the clinical characteristics, and whether there were differences in the clinical characteristics or the treatment between relapsed and non\u2010relapsed groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical history of all patients diagnosed with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> at the Asan Medical Center in South Korea from January 1996 to May 2012. <jats:styled-content style=\"fixed-case\">NBD<\/jats:styled-content> was defined as neurological symptoms and compatible abnormalities identified by magnetic resononance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 624 <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients, 22 were diagnosed with <jats:styled-content style=\"fixed-case\">NBD<\/jats:styled-content>. The common initial neurological symptoms were headache, gait disturbance and dysarthria. The common involved sites were the diencephalon, including internal capsule, the thalamus and basal ganglia, followed by the brainstem. An increased signal intensity on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2\u2010weighted images was the most common finding. All patients had an improved disease state after steroid treatment, regardless of combined treatment with cyclophosphamide. However, eight patients experienced a disease recurrence at 7.3\u00a0\u00b1\u00a05.1\u00a0months after treatment. There were no significant differences in treatment patterns between the relapsed group and the non\u2010relapsed group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NBD<\/jats:styled-content> may present with various neurologic manifestations with multifocal diencephalon and brainstem involvement. Most <jats:styled-content style=\"fixed-case\">NBD<\/jats:styled-content> patients had a good clinical outcome after steroid treatment, with or without a cytotoxic agent, but showed a pattern of relapse\u2013remission. Therefore, careful long\u2010term follow\u2010up is needed in most cases of <jats:styled-content style=\"fixed-case\">NBD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12265","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T07:18:59Z","timestamp":1391843939000},"page":"453-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Neuro\u2010beh\u00e7et's disease in South Korea: clinical characteristics and treatment response"],"prefix":"10.1111","volume":"17","author":[{"given":"Da\u2010Lim","family":"Yoon","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of 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