{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T09:03:15Z","timestamp":1718701395647},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Unit of Rheumatology"},{"name":"Department of Internal Medicine"},{"name":"Department of Physical Medicine and Rehabilitation"},{"name":"SKIMS"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of our study was to determine the genetic associations between polymorphisms of the <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1 gene (<jats:italic>\u2010308G\/A<\/jats:italic> and <jats:italic>\u2010238G\/A<\/jats:italic>) with disease susceptibility and severity in patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) in an ethnic <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ashmiri population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Allele and genotype frequencies of <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010308G\/A<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010238G\/A<\/jats:italic> polymorphisms were compared between 150 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients and 200 healthy controls by using polymerase chain reaction \u2013 restriction fragment length polymorphism method. Demographic, clinical and serological data were prospectively evaluated. Disease activity score (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not find any significant association between <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010308G\/A<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010238G\/A<\/jats:italic> polymorphism and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> risk (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05), but <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010308<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content><\/jats:italic> genotype was associated significantly with rheumatoid factor seropositivity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010238<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content><\/jats:italic> genotype was associated with swollen joint count &lt;\u00a05 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) as well as with less severe disease activity as measured by <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest the possible roles of <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010308<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><\/jats:italic>\u03b1<jats:italic>\u2010238<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content><\/jats:italic> as important determinants for the development of certain manifestations and disease severity in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> in ethnic <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ashmiri population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12270","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T05:07:09Z","timestamp":1388466429000},"page":"362-369","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The association between <i><scp>TNF<\/scp><\/i>\u03b1 gene polymorphisms and susceptibility to rheumatoid arthritis in an ethnic <scp>K<\/scp>ashmiri population: relationship with disease activity and severity 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