{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:49:34Z","timestamp":1760820574607},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Various coagulation disorders have been reported to explain hypercoagulability state in Behcet's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>). A possible negative association between human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010B51 and increased homocysteine level has been suggested in a previous report from Iranian patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. The aim of this study was to find any possible relationship between plasma homocysteine levels and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B51.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a case\u2010control study, <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients (fulfilling the new International Criteria for <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) and controls (who had similar clinical symptoms but <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> was clinically excluded in them) were included. Mean plasma homocysteine levels measured by enzyme\u2010linked immunosorbent assay in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B51 positive and negative individuals both in patients and controls were compared by <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney test and analysis of variance (<jats:italic>F<\/jats:italic>\u2010test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients and 152 controls were recruited. There was no significant difference between <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B51 positive and negative individuals either in the mean plasma homocysteine levels (13.59\u00a0\u00b1\u00a09.03 <jats:italic>vs<\/jats:italic>. 12.95\u00a0\u00b1\u00a04.98\u00a0\u03bcmol\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.514), or in the prevalence of hyperhomocysteinemia (17% <jats:italic>vs<\/jats:italic>. 21.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.504). This was true both for <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and control groups. In <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B51 positive and negative <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients, mean plasma homocysteine levels were 14.29\u00a0\u00b1\u00a012.02 and 12.62\u00a0\u00b1\u00a04.79\u00a0\u03bcmol\/L, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.33), and the prevalence of hyperhomocysteinemia was 20.8% versus 19.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.55). In the control group, the mean plasma homocysteine levels in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B51 positive and negative individuals were 12.85\u00a0\u00b1\u00a04.28 and 13.14\u00a0\u00b1\u00a05.10\u00a0\u03bcmol\/L, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.794), and the prevalence of hyperhomocysteinemia was 13% versus 22.1% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.23). The difference was non\u2010significant regarding sex (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.71) and disease activity (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In contrast to our previous report, we found no relationship between plasma homocysteine levels and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B51 in this study, either in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> or in the control group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12271","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T06:32:44Z","timestamp":1389853964000},"page":"466-470","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The relationship between plasma homocysteine level and <scp>HLA<\/scp>\u2010B51 in patients with <scp>B<\/scp>ehcet's disease: a 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