{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T17:53:10Z","timestamp":1743011590679},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Systemic lupus erythematosus (SLE<\/jats:styled-content>) presents as the abnormal activation and over\u2010proliferation of immune competent cells. Few studies have characterized the role of natural killer (NK<\/jats:styled-content>) and NK<\/jats:styled-content> T (NKT<\/jats:styled-content>) cells in the pathogenesis of SLE<\/jats:styled-content>, and therefore a consensus has not been reached as yet.<\/jats:p><\/jats:sec>Method<\/jats:title>Thirty\u2010two patients with new\u2010onset SLE<\/jats:styled-content> and 15 healthy controls were recruited. Activated and inhibitory NK<\/jats:styled-content> and NKT<\/jats:styled-content> cells in peripheral blood were quantified by flow cytometry. The proportions of spontaneous and stimulated interferon (IFN<\/jats:styled-content>)\u2010\u03b3+<\/jats:sup> NK<\/jats:styled-content> and NKT<\/jats:styled-content> cells and CD<\/jats:styled-content>107a+<\/jats:sup> NK<\/jats:styled-content> cells was examined. Finally, the potential relationship between the cell subsets and clinical indexes was analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>The proportions of NK<\/jats:styled-content> and NKT<\/jats:styled-content> cells (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.002 and 0.004, respectively) as well as the proportions of NKG<\/jats:styled-content>2C+<\/jats:sup> NK<\/jats:styled-content> cells, inhibitory NK<\/jats:styled-content> and NKT<\/jats:styled-content> cell subsets (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.016, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.019, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.049, and P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.028, respectively) in SLE<\/jats:styled-content> patients were significantly lower than those in controls. In contrast, the proportions of activated NK<\/jats:styled-content> cells and NKT<\/jats:styled-content> cell subsets were significantly higher (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.036, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.034, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.005, and P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.007, respectively). Moreover, the proportions of stimulated IFN<\/jats:styled-content>\u2010\u03b3+<\/jats:sup> NKT<\/jats:styled-content> cells were significantly higher than in the controls, and the proportions of stimulated CD<\/jats:styled-content>107a+<\/jats:sup> NKT<\/jats:styled-content> cells in SLE<\/jats:styled-content> patients were significantly lower than in the controls (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.032 and P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.02, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Lower proportions of NK<\/jats:styled-content> and NKT<\/jats:styled-content> cells, higher proportions of activated NK<\/jats:styled-content> cells and activated NKT<\/jats:styled-content> cells, lower proportions of inhibitory NK<\/jats:styled-content> and NKT<\/jats:styled-content> cells, higher NKT<\/jats:styled-content> cell activity, and lower NKT<\/jats:styled-content> cell degranulation may induce the autoimmune reaction involved in the pathogenesis of SLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12289","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T07:36:51Z","timestamp":1392277011000},"page":"613-621","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differential expression of natural killer activating and inhibitory receptors in patients with newly diagnosed systemic lupus erythematosus"],"prefix":"10.1111","volume":"19","author":[{"given":"Zhuang","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Rheumatology The First Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Fang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Key Laboratory for Zoonosis Research Ministry of Education The First Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002625"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.10.1639"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4049\/jimmunol.160.1.51","article-title":"A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL\u2010lpr\/lpr mice","volume":"160","author":"Chan O","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1088"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930290005864"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.08.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.11.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103478"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00457.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-24180-9_7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02822.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30313"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.07.016"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/79792"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030630"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/82698"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1028"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200423594"},{"issue":"1","key":"e_1_2_7_23_1","first-page":"171","article-title":"A killing defect of natural killer cells as an underlying immunologic abnormality in childhood systemic lupus erythematosus","volume":"23","author":"Yabuhara A","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339300200404"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.339"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<884::AID-ANR145>3.0.CO;2-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02887.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1322-9"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1138"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8016643"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00099-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.6"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO;2-S"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.2211"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-215491"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12289","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:36:33Z","timestamp":1696462593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,13]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/1756-185X.12289"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12289","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,13]]},"assertion":[{"value":"2014-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}