{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:05:03Z","timestamp":1789985103185,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Higher Education of Poland","award":["N N402 472737"],"award-info":[{"award-number":["N N402 472737"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n T cell abnormalities with a focus on\n T<\/jats:styled-content>\n h17 cells have been associated with the pathogenesis of systemic sclerosis (\n SS<\/jats:styled-content>\n c) and interstitial lung disease (\n ILD<\/jats:styled-content>\n ). The aim of this study was to evaluate serum levels of interleukin (\n IL<\/jats:styled-content>\n )\u201017,\n IL<\/jats:styled-content>\n \u201021 and\n IL<\/jats:styled-content>\n \u201023 in\n SS<\/jats:styled-content>\n c patients and to assess their relationship with\n ILD<\/jats:styled-content>\n \u2010\n SS<\/jats:styled-content>\n c.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty\u2010eight patients with\n SS<\/jats:styled-content>\n c and 39 healthy controls were recruited. Serum\n IL<\/jats:styled-content>\n \u201017,\n IL<\/jats:styled-content>\n \u201021 and\n IL<\/jats:styled-content>\n \u201023 levels were examined using enzyme\u2010linked immunosorbent assay (\n ELISA<\/jats:styled-content>\n ). Lung involvement of\n SS<\/jats:styled-content>\n c patients was assessed functionally (diffusing capacity of the lung for carbon monoxide [\n DLCO<\/jats:styled-content>\n ], body plethysmography) and radiologically (using average disease extent on high resolution computed tomography [\n HRCT<\/jats:styled-content>\n ] of the lungs according to the percentage of interstitial changes and quantified with a 30\u2010point Warrick score) in 29\n SS<\/jats:styled-content>\n c patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Serum\n IL<\/jats:styled-content>\n \u201017 and\n IL<\/jats:styled-content>\n \u201023 levels were significantly decreased and\n IL<\/jats:styled-content>\n \u201021 levels were elevated in\n SS<\/jats:styled-content>\n c patients when compared with controls (\n P<\/jats:italic>\n \u00a0<\u00a00.001,\n P<\/jats:italic>\n \u00a0<\u00a00.001,\n P<\/jats:italic>\n \u00a0<\u00a00.01, respectively). The level of\n IL<\/jats:styled-content>\n \u201017 was negatively associated with disease duration (\n P<\/jats:italic>\n \u00a0=\u00a00.01) and positively with\n HRCT<\/jats:styled-content>\n Warrick score (\n P<\/jats:italic>\n \u00a0=\u00a00.03).\n IL<\/jats:styled-content>\n \u201023 concentration negatively correlated with\n DLCO<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.04), total lung capacity (\n TLC<\/jats:styled-content>\n ) (\n P<\/jats:italic>\n \u00a0=\u00a00.01) and the 6\u2010min walk test distance (\n P<\/jats:italic>\n \u00a0=\u00a00.03). No associations were found between the cytokine levels and the average extent of the disease on\n HRCT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n While the relationship between\n T<\/jats:styled-content>\n h17\u2010associated cytokines and\n ILD<\/jats:styled-content>\n \u2010\n SS<\/jats:styled-content>\n c needs to be verified in a larger cohort of patients, the changes in concentrations of\n IL<\/jats:styled-content>\n \u201017,\n IL<\/jats:styled-content>\n \u201021 and\n IL<\/jats:styled-content>\n \u201023 support the hypothesis that these cytokines may play a role in the pathogenesis of\n SS<\/jats:styled-content>\n c.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.12290","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T07:25:21Z","timestamp":1390893921000},"page":"664-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Interleukin\u201017 and interleukin\u201023: importance in the pathogenesis of lung impairment in patients with systemic sclerosis"],"prefix":"10.1111","volume":"17","author":[{"given":"Anna","family":"Olewicz\u2010Gawlik","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Poznan University of Medical Sciences Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Danczak\u2010Pazdrowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology Poznan University of Medical Sciences Poznan 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