{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:15:00Z","timestamp":1777356900476,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,23]],"date-time":"2014-02-23T00:00:00Z","timestamp":1393113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Malaya Research Funds","award":["P0090\/2012A and BK020-2011B"],"award-info":[{"award-number":["P0090\/2012A and BK020-2011B"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical and antibody profile of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) in a Malaysian cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c in <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>alaya <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entre from <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch to <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2012 were included in this study. In addition to clinical characterization, all subjects underwent autoantibody testing using Euroline immunoblot assay. The association between clinical features and autoantibody profile was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 31, predominantly <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese (45.2%), subjects. Limited cutaneous disease was the most common subtype (71%). Raynaud's phenomenon was the most commonly observed feature (83.9%). Nine (29%) had esophageal dysmotility symptoms and 23 (74.2%), including all patients with diffuse <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, had symptoms of gastro\u2010esophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>). Restrictive pattern on pulmonary function test and evidence of lung fibrosis were seen in more than 70% of patients. Echocardiographic evidence of pulmonary arterial hypertension was seen in 58.1%. Telangiectasia, calcinosis, digital ulcers, digital pulp loss or pitting were seen more commonly in the diffuse subtype. The two most prevalent autoantibodies were anti\u2010Scl\u201070 and anti\u2010Ro\u201052. The presence of anti\u2010Scl\u201070 was significantly associated with restrictive lung disease (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.05). Anti\u2010Ro\u201052 was associated with control subjects with other autoimmune diseases (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.043). The presence of anti\u2010<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\u2010Scl\u201075 was associated with overlap syndrome (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.032). Patients with anticentromere antibodies were more likely to have vasculitic rash (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Malaysia, <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c most commonly affects the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese. Limited cutaneous is more common than diffuse subtype. Features of <jats:styled-content style=\"fixed-case\">CREST<\/jats:styled-content> (calcinosis, Reynaud disease, esophageal dysmotility, sclerodactyly, telangiectasia) are more commonly observed in the diffuse cutaneous subgroup. <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nti\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cl\u201070 and anti\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>o\u201052 antibodies are promising biomarkers for pulmonary involvement in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12322","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:56:30Z","timestamp":1393264590000},"page":"459-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical and autoantibody profile in systemic sclerosis: baseline 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