{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:55:32Z","timestamp":1793652932249,"version":"4.5.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The present study aimed at investigating the effects of Lactobacillus casei<\/jats:italic> 01 supplementation on symptoms and inflammatory biomarkers of rheumatoid arthritis (RA<\/jats:styled-content>) in women.<\/jats:p><\/jats:sec>Method<\/jats:title>In this randomized double\u2010blind clinical trial, female patients with established RA<\/jats:styled-content> for more than 1\u00a0year, 20\u201380\u00a0years of age and body mass index (BMI<\/jats:styled-content>) lower than 40, who followed stable medication for 3\u00a0months prior to the supplementation, were randomly allocated to receive either one capsule containing 108<\/jats:sup> colony forming units (CFU<\/jats:styled-content>) of L.\u00a0casei<\/jats:italic> 01, or a placebo for 8\u00a0weeks; allocation was stratified by BMI<\/jats:styled-content> and menopausal status. Disease activity score\u201028 (DAS<\/jats:styled-content>28) was calculated, European League Against Rheumatism (EULAR<\/jats:styled-content>) response was evaluated and the cytokines, interleukin (IL<\/jats:styled-content>)\u20101\u03b2, IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u201010, IL<\/jats:styled-content>\u201012 and tumor necrosis factor (TNF<\/jats:styled-content>)\u2010\u03b1 were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty patients were recruited in each group; 22 and 24 patients were analyzed in the probiotic and placebo groups, respectively. L.\u00a0casei<\/jats:italic> 01 supplementation decreased serum high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) levels, tender and swollen joint counts, global health (GH<\/jats:styled-content>) score and DAS<\/jats:styled-content>28 (P\u00a0<\/jats:italic><\u00a00.05). More patients in the L.\u00a0casei<\/jats:italic> 01 group had moderate response to the treatment, based on the EULAR<\/jats:styled-content> criteria, at the end of the study (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01). At the end of the study, a significant difference was observed between the two groups for IL<\/jats:styled-content>\u201010, IL<\/jats:styled-content>\u201012 and TNF<\/jats:styled-content>\u2010\u03b1 changes through the study course (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05), in favor of the probiotic group. No adverse effects were reported for the intervention.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Probiotic supplementation may be an appropriate adjunct therapy for RA<\/jats:styled-content> patients and help alleviate symptoms and improve inflammatory cytokines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12333","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T06:12:54Z","timestamp":1395900774000},"page":"519-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":229,"title":["Effects of L<\/scp>actobacillus casei<\/i> supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double\u2010blind clinical trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Beitullah","family":"Alipour","sequence":"first","affiliation":[{"name":"Department of Community Nutrition Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Homayouni\u2010Rad","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Vaghef\u2010Mehrabany","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Biochemistry and Diet Therapy Faculty of Nutrition Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakineh Khatoun","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Vaghef\u2010Mehrabany","sequence":"additional","affiliation":[{"name":"Department of Nutrition Faculty of Nutrition and Diet Therapy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Asghari\u2010Jafarabadi","sequence":"additional","affiliation":[{"name":"Traffic Injury Prevention Research Center Faculty of Health Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Nakhjavani","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Mohtadi\u2010Nia","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2003","volume-title":"Cecil Medicine","author":"O'Dell JR","year":"2008"},{"key":"e_1_2_8_3_1","first-page":"189","volume-title":"Rheumatoid Arthritis\u2010Etiology, Consequences and Co\u2010morbidities","author":"Zyrianova Y","year":"2011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05938.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.11.1030"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.7.689"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.1.64"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.121"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(02)00235-0"},{"key":"e_1_2_8_10_1","unstructured":"Anonymous(2002)Guidelines for the evaluation of probiotics in food Food and Agriculture Organization of the United Nations and World Health Organization Expert Consultation Report.http:\/\/www.who.int\/foodsafety\/publications\/fs_management\/probiotics2\/en. 11\u20131. 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