{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T10:48:00Z","timestamp":1721472480977},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T00:00:00Z","timestamp":1396569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>The association of malignancy with autoimmune rheumatic diseases has been a subject of investigation. It has been shown that there is increased risk of malignancies, mainly non\u2010Hodgkin lymphoma, in patients with autoimmune disorders. There is scarcity of data about malignancy in juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>). We report the occurrence of anaplastic large cell lymphoma in a patient with systemic onset juvenile idiopathic arthritis treated with low dose methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>). A relationship between <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> treatment and the occurrence of lymphoma in autoimmune diseases has been suggested. The hypothesis that <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> has a role in the aetiology of lymphoproliferative disorders is supported by the observation of spontaneous remission of lymphoma in few cases on cessation of <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> therapy. However, systemic onset juvenile idiopathic arthritis patients receiving <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> must be periodically examined for the development of lymphoproliferative disorder especially if the disease is difficult to control or patient develop new symptoms on therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12361","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T07:15:49Z","timestamp":1396595749000},"page":"573-577","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anaplastic large cell lymphoma in a patient with systemic onset juvenile arthritis: case report and review of literature"],"prefix":"10.1111","volume":"17","author":[{"given":"Bharat K.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T.","family":"Antony","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surendra K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debdutta","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vir S.","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100711"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34348"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009741003742722"},{"key":"e_1_2_4_5_1","first-page":"810","article-title":"Reversible methotrexate\u2010associated lymphoproliferative disease evolving into Hodgkin's disease","volume":"27","author":"Moseley AC","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21003"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0051-x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1184-0"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/R2Q9CCUVTLRYCF3H"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.12.3681"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.6.1943"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199920060-00002"},{"key":"e_1_2_4_14_1","first-page":"1245","article-title":"Hodgkin's disease in a patient with juvenile rheumatoid arthritis taking weekly low dose methotrexate","volume":"25","author":"Londino AV","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.1.47"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.073098"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204163261602"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12361","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:13:12Z","timestamp":1695496392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,4]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/1756-185X.12361"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12361","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,4]]},"assertion":[{"value":"2014-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}