{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:11:10Z","timestamp":1770412270994,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T00:00:00Z","timestamp":1401062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172850"],"award-info":[{"award-number":["81172850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the value of ultrasonography (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>) for diagnosing synovitis associated with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Bilateral metacarpophalangeal (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>), proximal interphalangeal (<jats:styled-content style=\"fixed-case\">PIP<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> and wrist joints of 46 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients and 35 healthy controls were evaluated by quantitative and semiquantitative <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>. Wrists on more severely affected sides of 20 of the 46 patients also underwent magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> results were compared. The <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> cutoff to distinguish pathology was calculated. The two <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> methods were compared and the correlation between quantitative methods and clinical serologic markers was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The imaging techniques (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) for detecting synovitis produced consistent results (\u03b3\u00a0=\u00a00.70\u20130.77, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). When the cutoffs for the <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIP<\/jats:styled-content> joints were 2.5 and 2.6\u00a0mm, respectively; the sensitivities\/specificities were 82.8%\/85.8% and 98.2%\/84.8%, respectively. When the cutoff for the wrist was 5.2\u00a0mm, the sensitivity\/specificity was 93.4%\/93.4%. The average synovial membrane thickness was positively related to biochemical markers erythrocyte sedimentation rate, C\u2010reactive protein, anticyclic citrullinated peptide antibody, and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ctivity Index of 28 joints (\u03b3\u00a0=\u00a00.307\u20130.614; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.020, 0.038, 0.01, &lt;\u00a00.001, respectively) but was poorly related to rheumatoid factor immunoglobulin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> (\u03b3\u00a0=\u00a00.06\u20130.115; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.45, 0.45, 0.62, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> is a valid method for diagnosing early\u2010stage synovitis, with high\u2010accuracy cutoffs for <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PIP<\/jats:styled-content> and wrist joints set at 2.5, 2.6 and 5.2\u00a0mm. The mean synovial thicknesses of the bilateral wrist, <jats:styled-content style=\"fixed-case\">MCP II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIP II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> joints can be used to assess disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12390","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T13:02:28Z","timestamp":1401109348000},"page":"767-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Value of ultrasonography for diagnosis of synovitis associated with rheumatoid arthritis"],"prefix":"10.1111","volume":"17","author":[{"given":"Hua","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Rheumatology The Chenzhou First People's Hospital Changsha 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