{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:52:26Z","timestamp":1760122346166},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T00:00:00Z","timestamp":1400889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to analyze possible autonomic nerve system alterations and assess the efficacy of heart rate variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>) analysis in anticipation of cardiovascular risks in pediatric patients with familial Mediterranean fever (<jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study, cardiac autonomic functions were investigated in children with <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> by analyzing <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> and its other probable cardiac effects by echocardiography. We studied 70 pediatric patients with <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> and 50 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The time\u2010domain parameters of <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> were compared between the <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> and control groups. <jats:styled-content style=\"fixed-case\">SDNN<\/jats:styled-content> (standard deviation of all <jats:styled-content style=\"fixed-case\">NN<\/jats:styled-content> intervals) was significantly decreased in patients with <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> as compared to control subjects. The other time\u2010domain parameters of <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> and the frequency\u2010domain parameters of <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> were similar in both groups. Frequency\u2010dependent <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> parameters were similar in both groups, as were conventional echocardiographic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> is a convenient and reliable technique for evaluation of autonomic functions. There are only a few studies on the assessment of autonomic functions by means of <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> in adult <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> patients but not in pediatric patients. Further studies are required to assess whether there is autonomic dysfunction in children with <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12401","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T07:24:09Z","timestamp":1400916249000},"page":"2086-2092","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of autonomic functions in children with familial Mediterranean fever by using heart rate variability measurements"],"prefix":"10.1111","volume":"20","author":[{"given":"Kursat","family":"Fidanci","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Gulhane Military Medical Faculty Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Gulgun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology 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