{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:28:36Z","timestamp":1776425316530,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007831","name":"Capital Health","doi-asserted-by":"publisher","award":["2011\u20104021\u201004"],"award-info":[{"award-number":["2011\u20104021\u201004"]}],"id":[{"id":"10.13039\/100007831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the practicability of magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) in confirming the diagnosis of clinically suspected rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), when anti\u2010cyclic citrullinated peptide antibody and radiographic erosions are absent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively involved 31 treatment\u2010naive patients with early inflammatory arthritis. At the initial visit, X\u2010rays and gadolinium\u2010enhanced <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> of both hands, as well as serological examinations and acute phase reactants were performed. The scores of synovitis, bone edema, bone erosion and tenosynovitis of metacarpophalangeal and wrist joints were evaluated using the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scoring system. For all the patients, radiographs at baseline were normal and anti\u2010cyclic citrullinated peptide antibodies were negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of follow\u2010up(median 15\u00a0months, range 12\u201320\u00a0months), 22 patients were diagnosed as having <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> according to 1987 American College of Rheumatology criteria. Bone edema, erosions, synovitis and tenosynovitis were observed in all the patients. However, the frequency of symmetric synovitis in wrists was significantly higher in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> group. Moreover this group turned out to have significantly higher <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> bone erosion score in wrists. Further, receiver operating characteristic curve analysis revealed a positive wrist bone erosion score at 5, with a specificity of 78% and a sensitivity of 68%. There was no significant difference between the two groups with respect to metacarpophalangeal synovitis, metacarpophalangeal bone erosion, bone edema or tenosynovitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> evidence of symmetric synovitis at wrist and a high bone erosion score at that site may assist in making an early diagnosis of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> in those patients who are negative for anti\u2010cyclic citrullinated peptide antibody.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12420","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T02:36:26Z","timestamp":1418092586000},"page":"859-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Early prediction of rheumatoid arthritis by magnetic resonance imaging in the absence of anti\u2010cyclic citrullinated peptide antibodies and radiographic erosions in undifferentiated inflammatory arthritis patients: a prospective study"],"prefix":"10.1111","volume":"18","author":[{"given":"Lanlan","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangtao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing 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