{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:19:51Z","timestamp":1791181191873,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Matrix metalloproteinase\u20103 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103) plays a pivotal role in the destruction of bone and degradation of cartilage components in rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). We aimed in this study to analyze the relation between baseline levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 and the progression of joint damage in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010one untreated <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients with joint symptoms for &lt;1\u00a0year were evaluated at baseline and after 12\u00a0months as regards erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>), C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), rheumatoid factor (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>), anti\u2010cyclic citrullinated peptide (anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>) and plain X\u2010ray of both hands and wrists. Baseline levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 were measured by enzyme\u2010linked immunosorbent assay and magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) of hands\/wrists was performed. Disease Activity Score (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) and Health Assessment Questionnaire (<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>) were performed at baseline evaluation and after 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 levels were significantly higher in the high\u2010progression group compared with the low\u2010progression one (95.75\u00a0\u00b1\u00a042.84 <jats:italic>vs<\/jats:italic>. 50.45\u00a0\u00b1\u00a012.83, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). There was a positive correlation between baseline levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> erosion score and other baseline clinical parameters, except for <jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> and the van der Heijde modification of the Sharp scoring system (SvdH) scores, while after 12\u00a0months, there were high positive correlations between <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 and SvdH score, as well as all parameters except for <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum baseline levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 are strong prognostic markers of disease activity, and act well as an early predictor of progressive joint damage in recent\u2010onset <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12434","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T14:00:27Z","timestamp":1412690427000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Baseline serum level of matrix metalloproteinase\u20103 as a biomarker of progressive joint damage in rheumatoid arthritis patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Sahar Mahfouz Abdel","family":"Galil","sequence":"first","affiliation":[{"name":"Department of Rheumatology &amp; Rehabilitation Faculty of Medicine Zagazig University Zagazig Egypt"},{"name":"Department of Medicine Department Faculty of Medicine Umm Al\u2010Qura University Holly Markkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer Mohamed","family":"El\u2010Shafey","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Rehabilitation Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda A.","family":"Hagrass","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed El","family":"Sammak","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17402520500233510"},{"key":"e_1_2_6_3_1","first-page":"E98","article-title":"Serum matrix metalloproteinase\u20103 as predictor of joint destruction in rheumatoid arthritis, treated with non\u2010biological disease modifying anti\u2010rheumatic drugs","volume":"56","author":"Mamehara A","year":"2010","journal-title":"Kobe J Med Sci"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22923"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg037"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022434"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.2.161"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0098"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1919"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32832498f0"},{"key":"e_1_2_6_11_1","first-page":"585","article-title":"Evidence of significant radiographic damage in rheumatoid arthritis within the first 2\u00a0years of disease","volume":"16","author":"Fuchs HA","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.11.1094"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.130310"},{"issue":"12","key":"e_1_2_6_14_1","first-page":"2325","article-title":"Usefulness of serum matrix metalloproteinase\u20103 (MMP\u20103) levels in the diagnosis of rheumatoid arthritis","volume":"60","author":"Yamanaka H","year":"2002","journal-title":"Nihon Rinsho"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_6_17_1","first-page":"743","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"26","author":"Heijde D","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_6_18_1","first-page":"1385","article-title":"OMERACT rheumatoid arthritis magnetic resonance imaging studies. 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