{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:34:22Z","timestamp":1759422862626},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We studied the usefulness of magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) in detecting subclinical inflammation in patients with asymptomatic <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and tested the hypothesis of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201018 as a marker of disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ctivity <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core of 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) &lt;\u00a02.6 were evaluated. The patients underwent clinical evaluation, laboratory tests and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> assessment. Imaging of bilateral hands and wrists was performed using validated acquisition and scoring techniques. Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 levels were concurrently measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> assessments showed that 92.3% and 76.9% of patients had synovitis and bone marrow edema, respectively, despite being in clinical remission. Eight out of 12 patients (66.7%) had erosions on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> which were not visualised on plain radiographs. Of all the 182 joints studied for synovitis on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, only one had clinical evidence of joint swelling. Comparison of the total sum scores of synovitis between the right and left hand and wrist joints of individual patients showed a significant difference between the two sides. Measurements of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 indicated that a large proportion (54%) of the patients had undetectable or very low levels of the cytokine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> is more sensitive in detecting erosions compared with <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010rays, and is superior in its ability to detect subclinical inflammation in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients. Despite being in clinical remission, a large majority of patients had imaging\u2010detected synovitis and bone marrow edema. Our study highlights the usefulness of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> for the accurate evaluation of disease activity. In the utility of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, it may be important to assess bilateral hands and wrists, instead of limiting to the dominant side.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12448","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T04:59:35Z","timestamp":1408078775000},"page":"790-798","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of magnetic resonance imaging in detecting subclinical synovitis in rheumatoid arthritis and correlation of imaging findings with interleukin\u201018 levels"],"prefix":"10.1111","volume":"19","author":[{"given":"Li\u2010Ching","family":"Chew","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Singapore General Hospital Singapore"},{"name":"Duke\u2010NUS Graduate Medical School Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chandra Mohan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Department of Diagnostic Radiology Singapore General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai Peng","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Singapore General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok Yong","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Singapore General Hospital Singapore"},{"name":"Duke\u2010NUS Graduate Medical School Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Thumboo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Singapore General Hospital Singapore"},{"name":"Duke\u2010NUS Graduate Medical School Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10148"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh297"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg072"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21235"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.149765"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22190"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.8.770"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.3.156"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.11.916"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_14_1","first-page":"1385","article-title":"OMERACT rheumatoid arthritis magnetic resonance imaging studies. 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