{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:28:47Z","timestamp":1791210527991,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vice Chancellor of Tabriz University of Medical Sciences"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study was designed to examine the effect of Burdock root tea on inflammatory markers and oxidative stress indicators in patients with knee osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six patients (10 men and 26 women) aged 50\u201370\u00a0years old with knee osteoarthritis referred to the Physical Medicine and Rehabilitation Department of the Tabriz University of Medical Sciences Hospitals, were selected for the study and randomly divided into two groups. Anthropometric measurements, including height, weight and body mass index (BMI) were measured. For all individuals along the 42\u00a0days of study period, the same drug treatments, including two lots of 500\u00a0mg acetaminophen twice a day and one glucosamine 500\u00a0mg once a day,were considered. The intervention group received daily three cups of Burdock root tea (each cup containing 2\u00a0g\/150\u00a0mL boiled water) half\u2010hour after the meal. The control group received three cups containing 150\u00a0cc boiled water daily. We assessed inflammatory markers such as high sensitivity C\u2010reactive protein (hs\u2010CRP) and interleukin\u20106 (IL\u20106) and oxidative stress indicators such as total antioxidants capacity (TAC), glutathione peroxidase (GPX), superoxide dismutase (SOD) and thiobarbituric acid reactive substances before and after the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that burdock root tea significantly decreased the levels of serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002), hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003) and malondialdehyde (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), while the levels of serum <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and activities of <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.009) were significantly increased. <jats:styled-content style=\"fixed-case\">GPX<\/jats:styled-content> activities increased but not significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggested that <jats:italic>Arctium lappa<\/jats:italic> L. root tea improves inflammatory status and oxidative stress in patients with knee osteoarthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12477","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T12:44:56Z","timestamp":1414500296000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Effects of <i>Arctium lappa<\/i> L. 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