{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:47:06Z","timestamp":1695620826462},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Endothelial progenitor cells (EPC<\/jats:styled-content>s) are unique populations which have reparative potential in overcoming endothelial damage and reducing cardiovascular risk. Patients with ankylosing spondylitis (AS<\/jats:styled-content>) have increased risk of cardiovascular morbidity and mortality. The aim of this study was to investigate the endothelial progenitor cell population in AS<\/jats:styled-content> patients and its potential relationships with disease variables.<\/jats:p><\/jats:sec>Methods<\/jats:title>Endothelial progenitor cells were measured in peripheral blood samples from 20 AS<\/jats:styled-content> and 20 healthy controls by flow cytometry on the basis of CD<\/jats:styled-content>34 and CD<\/jats:styled-content>133 expression. Disease activity was evaluated by using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI<\/jats:styled-content>). Functional ability was monitored by using Bath Ankylosing Spondylitis Functional Index (BASFI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>EPC<\/jats:styled-content>s were depleted in AS<\/jats:styled-content> patients as compared to healthy controls (CD<\/jats:styled-content>34+<\/jats:sup>\/CD<\/jats:styled-content>133+<\/jats:sup>: 0.027\u00a0\u00b1\u00a00.010% vs<\/jats:italic>. 0.044\u00a0\u00b1\u00a00.011%, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). EPC<\/jats:styled-content> depletions were significantly associated with disease duration (r\u00a0<\/jats:italic>=\u00a0\u22120.52, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.01), BASDAI<\/jats:styled-content> (r\u00a0<\/jats:italic>=\u00a0\u22120.45, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.04) and C\u2010reactive protein (r\u00a0<\/jats:italic>=\u00a0\u22120.5, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This is the first study to demonstrate endothelial progenitor cell depletion in AS<\/jats:styled-content> patients. EPC<\/jats:styled-content> depletions inversely correlate with disease duration, disease activity and inflammation, suggesting the pivotal role of inflammation in depletion of EPC<\/jats:styled-content>s. EPC<\/jats:styled-content> would possibly also serve as a therapeutic target for preventing cardiovascular disease in AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12487","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T13:13:36Z","timestamp":1414502016000},"page":"336-340","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endothelial progenitor cell biology in ankylosing spondylitis"],"prefix":"10.1111","volume":"18","author":[{"given":"Inderjeet","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Drug Research Punjabi University Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashit","family":"Syngle","sequence":"additional","affiliation":[{"name":"Cardio Rheuma and Healing Touch City Clinic Chandigarh and Fortis Multi Specialty Hospital Mohali 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