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The clinical score and paw thickness were measured. Mice were sacrificed on day 15, and the expression of tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in the serum were analyzed using enyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). Two pathologists independently measured the synovitis score. Micro\u2010computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) scans of the joints were performed to quantify joint destruction. The expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 from human fibroblast\u2010like synoviocytes (<jats:styled-content style=\"fixed-case\">FLS<\/jats:styled-content>s) after incubation with various doses of Tubastatin A (0, 0.75, 1.5, 3\u00a0\u03bcmol\/L) was measured using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical arthritis score was significantly attenuated and paw thickness was lower in the group treated with 100\u00a0mg\/kg Tubastatin A compared with those treated with vehicle alone. The synovitis score was significantly reduced in the 100\u00a0mg\/kg Tubastatin A\u2010treated group compared with the control group. Micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> showed that quantitative measures of joint destruction were significantly attenuated in the 100\u00a0mg\/kg Tubastatin A\u2010treated group compared with the control. The expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in the sera was lower in the mice treated with Tubastatin A compared with the control. The expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in human <jats:styled-content style=\"fixed-case\">FLS<\/jats:styled-content>s decreased dose\u2010dependently after incubation with Tubastatin A without affecting cell viability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tubastatin A successfully ameliorated synovial inflammation and protected against joint destruction in <jats:styled-content style=\"fixed-case\">CAIA<\/jats:styled-content> mice, at least in part, by modulating <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12501","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T08:29:13Z","timestamp":1419064153000},"page":"514-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A novel histone deacetylase 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