{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:24:12Z","timestamp":1774538652315,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Korean health care technology R&D project. ministry of health and welfare, republic of Korea","award":["HI10C2020"],"award-info":[{"award-number":["HI10C2020"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the occurrence of active tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) in patients who received both an interferon\u2010gamma release assay (the Quanti<jats:styled-content style=\"fixed-case\">FERON<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> Gold In\u2010Tube test [<jats:styled-content style=\"fixed-case\">QFT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GIT<\/jats:styled-content>]) and tuberculin skin test (<jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>) in comparison with those who received <jats:styled-content style=\"fixed-case\">QFT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GIT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> alone for the detection of latent <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> infection (<jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 842 patients who received <jats:styled-content style=\"fixed-case\">QFT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GIT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> and used biologic agents between January 2007 and December 2012 were recruited to determine the usefulness of <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> screening tests. The incidence of active <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> was calculated relative to the <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> screening method as the number of events per 100\u00a0000 person\u2010years exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> occurred in two of the patients who complied with an <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> prophylaxis strategy. The <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> incidence in the group that received both <jats:styled-content style=\"fixed-case\">QFT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GIT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> was 151.05 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 150.11\u2013151.98)\/100\u00a0000 person\u2010years, and the incidence was 169.78 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 168.73\u2013170.84)\/100\u00a0000 person\u2010years in the group that received only <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> occurred even in some patients who received <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> prophylaxis in compliance with national guidelines. The incidence of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> in patients who received either the <jats:styled-content style=\"fixed-case\">QFT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GIT<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> prophylaxis strategy or the <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> prophylaxis strategy alone was higher than the annual incidence of the general population of the Republic of Korea. It is not possible to conclude which of the <jats:styled-content style=\"fixed-case\">LTBI<\/jats:styled-content> prophylaxis strategies is superior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12515","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T15:19:36Z","timestamp":1414509576000},"page":"315-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the usefulness of interferon\u2010gamma release assays and the tuberculin skin test for the detection of latent <i>Mycobacterium tuberculosis<\/i> infections in Korean rheumatic patients who are candidates for biologic agents"],"prefix":"10.1111","volume":"18","author":[{"given":"Jae\u2010Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Guro Hospital Korea University College of Medicine Seoul 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