{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:52:00Z","timestamp":1793638320978,"version":"4.5.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International S&T Cooperation Program of China","award":["2013DFA30870"],"award-info":[{"award-number":["2013DFA30870"]}]},{"name":"Science and Technology Committee of Shanghai Municipality","award":["11DJ1400102"],"award-info":[{"award-number":["11DJ1400102"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Original studies have employed various genetic models in association analysis between\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">ABCG<\/jats:styled-content>\n                        2\n                      <\/jats:italic>\n                      Q141K (rs2231142) with gout risk and different or conflicting results, especially regarding the role of gender in this association. In addition, it is not clear whether the association varies by ethnicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Articles published before September 1, 2013 were extracted and registered into databases for the systematic review of this polymorphism. The quality of each study was scored based on predefined criteria. The genetic model was identified through stratification analysis, then a meta\u2010analysis including all publically available data was preformed to test the association between rs2231142 and gout risk. Potential sources of heterogeneity were sought out via stratification analysis and meta\u2010regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine case\u2013control studies involving 17\u00a0942 individuals were eligible for the meta\u2010analysis of rs2231142. Codominant model was the most appropriate genetic model to interpret the susceptibility cause. It showed that the rs2231142 T allele obviously increased gout risk, and\n                      <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\n                      was much stronger than\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\n                      <jats:italic>vs<\/jats:italic>\n                      .\n                      <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>\n                      :\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      , 4.10; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      <jats:italic>,<\/jats:italic>\n                      2.90\u20135.80;\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      <jats:italic>vs<\/jats:italic>\n                      .\n                      <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>\n                      :\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      , 1.71, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 1.39\u20132.10). In addition, gender and ethnicity were found to affect the association between the susceptibility of gout and rs2231142.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">ABCG<\/jats:styled-content>\n                        2\n                      <\/jats:italic>\n                      rs2231142 is an important genetic factor in increasing gout risk, and the difference in genetic association has been found between male and female populations. In addition, the degree of association has been found to vary with ethnicity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.12519","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T00:08:33Z","timestamp":1419984513000},"page":"382-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Association between\n                    <scp>ABCG<\/scp>\n                    2 Q141K polymorphism and gout risk affected by ethnicity and gender: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"18","author":[{"given":"Zheng","family":"Dong","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai 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