{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:03:22Z","timestamp":1780056202792,"version":"3.54.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To compare the diagnostic performance of rheumatoid factor (RF<\/jats:styled-content>) and anti\u2010cyclic citrullinated peptide antibody (anti\u2010CCP<\/jats:styled-content>) in the diagnosis of patients with rheumatoid arthritis (RA<\/jats:styled-content>) in Taiwan.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum concentrations of RF<\/jats:styled-content> and anti\u2010CCP<\/jats:styled-content> were measured in 246 cases, including 39 patients with RA<\/jats:styled-content> and 207 patients with other rheumatic diseases (non\u2010RA<\/jats:styled-content>). The age, sex, clinical presentation, RF<\/jats:styled-content>, anti\u2010CCP<\/jats:styled-content> results and the final diagnoses were recorded and analyzed. The sensitivity, specificity, positive predictive value (PPV<\/jats:styled-content>), negative predictive value (NPV<\/jats:styled-content>), positive likelihood ratio (LR<\/jats:styled-content>+) and negative likelihood ratio (LR<\/jats:styled-content>\u2212) were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Among all 246 patients, 39 (15.9%) were diagnosed with RA<\/jats:styled-content> and 207 (84.1%) were diagnosed with other rheumatic diseases (non\u2010RA<\/jats:styled-content>). In the diagnosis of RA<\/jats:styled-content>, the sensitivity, specificity, PPV<\/jats:styled-content>, NPV<\/jats:styled-content>, LR<\/jats:styled-content>+ and LR<\/jats:styled-content>\u2212 of the RF<\/jats:styled-content> test were 67%, 79%, 37%, 93%, 3.12, and 0.42, respectively. The corresponding data for the anti\u2010CCP<\/jats:styled-content> test were 79%, 98%, 86%, 96%, 32.91 and 0.21, respectively. The presence of either anti\u2010CCP<\/jats:styled-content> or RF<\/jats:styled-content> increased the sensitivity to 85%, and when they both were present, the specificity increased to 98%. Among the 39 RA<\/jats:styled-content> patients, 26 (66.7%) tested positive for RF<\/jats:styled-content>, and 31 (79.5%) tested positive for anti\u2010CCP<\/jats:styled-content>. RF<\/jats:styled-content> was positive in two of eight anti\u2010CCP<\/jats:styled-content>\u2010negative patients with RA<\/jats:styled-content>, and anti\u2010CCP<\/jats:styled-content> was positive in seven of 13 RF<\/jats:styled-content>\u2010negative patients with RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The RF<\/jats:styled-content> and anti\u2010CCP<\/jats:styled-content> tests are complementary, and the co\u2010detection of these antibodies can increase the detection rate and provide important clinical value in the diagnosis of RA<\/jats:styled-content>. Both anti\u2010CCP<\/jats:styled-content> and RF<\/jats:styled-content> positivity are useful for the diagnosis of RA<\/jats:styled-content>, and use of both tests together improves the diagnostic sensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12552","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T14:15:36Z","timestamp":1430748936000},"page":"880-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Diagnostic performance of anti\u2010cyclic citrullinated peptide and rheumatoid factor in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"19","author":[{"given":"Pi\u2010Yueh","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Chang\u2010Gung Memorial Hospital Tao\u2010Yuan Taiwan"},{"name":"Department of Medical Biotechnology and Laboratory Science Tao\u2010Yuan Taiwan"},{"name":"Chang Gung University 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