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An additional question was also developed by participating Australian and New Zealand rheumatologists. Each question was investigated with a systematic literature review. <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, Cochrane <jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content> and abstracts from 2010 to 2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis and risk of bias assessment. Using this evidence, 47 Australian and New Zealand rheumatologists developed national recommendations. For each recommendation the level of agreement was assessed and the level of evidence graded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Eleven recommendations were produced relating to the diagnosis of gout, different aspects of the management of gout, cardiovascular and renal comorbidities and the management of asymptomatic hyperuricemia. The mean level of agreement with the recommendations was 9.1 on a 1\u201310 scale, with 10 representing full agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eleven Australian and New Zealand recommendations on the diagnosis and management of gout were developed combining systematically reviewed evidence with local expertise, enhancing their utility in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12557","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T12:47:17Z","timestamp":1429274837000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Australian and New Zealand recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion in the 3e Initiative"],"prefix":"10.1111","volume":"18","author":[{"given":"Scott W.","family":"Graf","sequence":"first","affiliation":[{"name":"Rheumatology Unit and Department of General Medicine Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L.","family":"Whittle","sequence":"additional","affiliation":[{"name":"Rheumatology Unit The Queen Elizabeth Hospital Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir D.","family":"Wechalekar","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit Repatriation General Hospital Daw Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H. 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