{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:20:56Z","timestamp":1767676856839},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim and objectives<\/jats:title><jats:p>The aim and objectives are as follows: (i) to perform an automated segmentation of the hand from radiographs using a dual tree complex wavelet\u2010based watershed algorithm; ii) to compare the measured statistical features of the joint space of the hand using gray level co\u2010occurrence matrix (<jats:styled-content style=\"fixed-case\">GLCM<\/jats:styled-content>) method with standard diagnostic parameters of rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three patients with<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>and 17 age\u2010 and sex\u2010matched healthy controls were included in the study. The erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>), C\u2010reactive protein, rheumatoid factor, health assessment questionnaire score (<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>), disease activity score (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>) and hand radiographs of all the subjects were obtained. Joint space width and cortical thickness were measured in metacarpophalangeal joints (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>) and metacarpal bone semi\u2010automatically using<jats:styled-content style=\"fixed-case\">MIMICS<\/jats:styled-content>software. Dual tree complex wavelet transform\u2010based watershed algorithm was applied for automated segmentation, and feature extraction was performed using the<jats:styled-content style=\"fixed-case\">GLCM<\/jats:styled-content>method in hand radiographs of the total population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>53), the joint space width measured in the<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>3,<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>5 of the hand were reduced significantly (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) by 16.4%, 15.6%, and 17.5%, respectively compared to the normal group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>17). The measured combined cortical thickness at the second, third and fourth metacarpal bones of the hand were reduced significantly (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) by 9.5%, 12% and 8%, respectively in the<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>group compared to the normal group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The dual tree complex wavelet transform\u2010based watershed algorithm provided effective segmentation in the digitized hand radiographs. The standard diagnostic parameters for<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>were highly correlated with measured statistical features at<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>3 hand joint in the total population studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12559","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T23:32:50Z","timestamp":1428708770000},"page":"1120-1131","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Computer\u2010based measurements of joint space analysis using metacarpal morphometry in hand radiograph for evaluation of rheumatoid arthritis"],"prefix":"10.1111","volume":"20","author":[{"given":"U.","family":"Snekhalatha","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering SRM University Kattankulathur Chennai Tamilnadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Anburajan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering SRM University Kattankulathur Chennai Tamilnadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"http:\/\/www.who.int\/chp\/topics\/rheumatic\/en\/Accessed on February 21 2014."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_6_4_1","first-page":"S343","article-title":"Prevalence of rheumatic musculoskeletal disorders in west India nurbak population: bone and joint decade India Burden of disease project","volume":"56","author":"Lagu\u2010Joshi V","year":"2007","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.rheumatology.a031496"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/028418517701800415"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-3-13"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21802"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-265"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4163"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.387691"},{"key":"e_1_2_6_12_1","unstructured":"SharifBS ZarougSA ChesterEG OwenJP LeeEJ(1994)Bone edge detection in Hand radiographic images. Engineering in Medicine and Biology Society (EMBC). Proceedings of the 16th Annual International Conference of The IEEE 1 514\u20135."},{"issue":"1","key":"e_1_2_6_13_1","first-page":"191","article-title":"HANDX: a model\u2010based system for automatic segmentation of bones from digital hand radiographs","volume":"8","author":"Michael DJ","year":"1990","journal-title":"IEEE Trans Med Imaging"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-6111(03)00053-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0933-3657(93)90022-U"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-6111(95)00005-B"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1995.1016"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597402"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0973-3698(10)60373-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"issue":"1","key":"e_1_2_6_21_1","article-title":"Correlation between CCP levels and health assessment questionnaire in rheumatoid arthritis: a single center analysis","volume":"4","author":"Mohd shahrir MS","year":"2007","journal-title":"Internet J Rheumatol"},{"key":"e_1_2_6_22_1","first-page":"93","article-title":"The disease activity score and EULAR response criteria","volume":"23","author":"Fransen J","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_23_1","unstructured":"Online disease activity score calculator for rheumatoid arthritis Available fromhttp:\/\/www.das-score.nl. Accessed 2 June 2014."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280104"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199809)41:9<1583::AID-ART8>3.0.CO;2-H"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102474\u20103\u201013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.1999.0447"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/MSP.2005.1550194"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2003.819311"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/248393"},{"key":"e_1_2_6_31_1","first-page":"433","volume-title":"Mathematical Morphology in Image Processing","author":"Beucher S","year":"1993"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/30415751"},{"key":"e_1_2_6_33_1","volume-title":"Theory and Problem of Statistics and Economterics","author":"Salvatore D","year":"2011"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748909095032"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380704"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598983"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21829"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3056"},{"issue":"3","key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/acr.20394","article-title":"Abnormal bone geometry at the metacarpal bone shaft of Rheumatoid arthritis patients with maintained muscle\u2010bone relationship","volume":"63","author":"Eser P","year":"2011","journal-title":"Arthritis Care Res"},{"issue":"3","key":"e_1_2_6_40_1","first-page":"508","article-title":"Loss of cortical bone from the metacarpal diaphysis in patients with rheumatoid arthrtitis: independent effects of systemic inflammation and glucocorticoids","volume":"33","author":"Roldan JF","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20172"},{"key":"e_1_2_6_42_1","unstructured":"KauffmanJA SlumpCH BernelotMH(2004)Segmentation of radiographs hands with joint damage using customized active appearance model. In:PRORISC.15th Annual workshop on circuits systems and signal processing pp.261\u20135."},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2452061281"},{"key":"e_1_2_6_44_1","first-page":"47","article-title":"A fully Automated algorithm dedicated to computing metacarpo phalangeal and Interphalangeal joint cavity widths","volume":"16","author":"Zielinski B","year":"2007","journal-title":"Schedae Informaticae"},{"key":"e_1_2_6_45_1","unstructured":"SergioV(2010)Finger joint modeling from hand X\u2010ray images for assessing rheumatoid arthritis. Center de Visio per computador CVC Technical report #164 pp.1\u201330."}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T09:39:02Z","timestamp":1717839542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,10]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/1756-185X.12559"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12559","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,10]]},"assertion":[{"value":"2015-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}