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A recent genome\u2010wide association study has shown that the genes HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1<\/jats:italic> and HLA<\/jats:styled-content>\u2010DQ<\/jats:styled-content><\/jats:italic> conferred susceptibility to GPA<\/jats:styled-content> and MPA<\/jats:styled-content>, respectively. We investigated the linkage between putative AAV<\/jats:styled-content>\u2010related genes (HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1<\/jats:italic>, ARHGAP<\/jats:styled-content>18<\/jats:italic>, CD<\/jats:styled-content>226<\/jats:italic>, CTLA<\/jats:styled-content>\u20104<\/jats:italic>, MOSPD<\/jats:styled-content>2<\/jats:italic> and PRTN<\/jats:styled-content>3<\/jats:italic>) and AAV<\/jats:styled-content> in a Han Chinese population.<\/jats:p><\/jats:sec>Method<\/jats:title>A Sequenom MassAarray system (iPLEX<\/jats:styled-content> assay, Sequenom, San Diego, CA<\/jats:styled-content>, USA<\/jats:styled-content>) was used to genotype single nucleotide polymorphisms (SNP<\/jats:styled-content>s) in 176 Han Chinese patients with AAV<\/jats:styled-content> (100 with GPA<\/jats:styled-content>, 76 with MPA<\/jats:styled-content>) and 485 ethnically matched healthy controls.<\/jats:p><\/jats:sec>Result<\/jats:title>The frequency of the rs3117242 variant T allele (HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1<\/jats:italic>) was significantly higher in GPA<\/jats:styled-content> patients than in the controls (68.0% compared with 50.4%, OR<\/jats:styled-content>\u00a0=\u00a02.09, 95% CI<\/jats:styled-content>: 1.51\u20132.88, Bonferroni corrected P<\/jats:italic>\u2010value [Pc<\/jats:italic>]\u00a0=\u00a06.24E\u20105), but was not significantly different between MPA<\/jats:styled-content> patients and controls (Pc<\/jats:italic>\u00a0=\u00a00.14). The same results were obtained via genotype distribution and logistic regression analysis based on three genetic models. The allele and genotype distributions of the other polymorphisms were not significantly associated with AAV<\/jats:styled-content> patients as a whole or GPA<\/jats:styled-content> or MPA<\/jats:styled-content> patients considered separately.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The rs3117242 of HLA<\/jats:styled-content>\u2010DPB<\/jats:styled-content>1<\/jats:italic> could be considered a genetic risk factor for GPA<\/jats:styled-content> in Chinese Han people. These findings provide further insights and clues into the etiology of GPA<\/jats:styled-content> and MPA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12561","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T17:01:52Z","timestamp":1432746112000},"page":"1009-1015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["HLA<\/scp>\u2010DPB<\/scp>1 variant rs3117242 is associated with anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitides\u00a0in a Han Chinese population"],"prefix":"10.1111","volume":"20","author":[{"given":"Ziyan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing 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Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing 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