{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:20:42Z","timestamp":1761988842831},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To review existing literature on the prevalence\/incidence of coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>), and secondarily highlight risk factors for <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A PubMed and Cochrane Central Register of Controlled Trials search of studies (till 30 November 2013) relating to <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> was performed, retrieving 180 titles. Inclusion criteria: studies reporting <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> prevalence\/incidence in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c based on autopsy findings, coronary artery calcium scores, coronary angiographic findings and physician\/patient\u2010reported <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. Exclusion criteria: (i) not written in English; (ii) not concerned with human subjects; (iii) single case reports or review articles; (iv) genetic studies; and 95) other surrogate outcome measures of atherosclerosis. Quality assessment was done using the Newcastle\u2010Ottawa score (range 0\u20139).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen studies (Newcastle\u2010Ottawa score 5\u20138) were selected. Of eight studies with controls, seven reported increased <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> prevalence (10\u201356%) or incidence (2.3%) compared to controls (prevalence 2\u201344%; incidence 1.5%). Of five studies without controls, <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> prevalence was 8\u201332%. Five of six studies reported that traditional cardiovascular risk factors were similar\/reduced in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c compared to controls. <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c was an independent risk factor for <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>, in addition to age (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2), hypercholesterolaemia (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>3), male gender (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1), hypertension and diabetes (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1). Disease duration, renal involvement and pulmonary arterial hypertension were associated with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic sclerosis is associated with an increased prevalence\/incidence of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c is an independent risk factor for <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. The association of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c\u2010related factors requires further research. Meanwhile, patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c should be screened and treated for identified traditional cardiovascular risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12566","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T12:47:25Z","timestamp":1429274845000},"page":"276-286","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["A qualitative systematic review of the prevalence of coronary artery disease in systemic sclerosis"],"prefix":"10.1111","volume":"18","author":[{"given":"Hassan","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Singapore General Hospital Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiat R.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Singapore General Hospital Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea H. 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