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Sixty<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients recruited from<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>hanghai,<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina were matched on gender and age with 60 patients from a prospective early<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>cohort from the<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">SARAH<\/jats:styled-content>trial). The procedures of data collection in<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina followed the standard operating procedures employed in the<jats:styled-content style=\"fixed-case\">SARAH<\/jats:styled-content>trial. Outcome measures including<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ichigan<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>utcomes<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire (<jats:styled-content style=\"fixed-case\">MHQ<\/jats:styled-content>), medication history and physical assessments were used to assess functional ability and hand impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>patients reported significantly more hand pain (<jats:italic>P<\/jats:italic>\u00a0=<jats:italic>\u00a0<\/jats:italic>0.015), less satisfaction with dominant hand performance (<jats:italic>P<\/jats:italic>\u00a0\u00a0=\u00a00.040), more swollen and tender joints (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.016 and<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and greater dexterity of both dominant and non\u2010dominant hands (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001 and<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), while<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients had higher disease activity indicated by erythrocyte sedimentation rate and<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein, more rheumatoid factor, less satisfaction in both dominant and non\u2010dominant hand appearances (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001 and<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, respectively) and greater dominant hand deformity (<jats:italic>P\u00a0\u00a0<\/jats:italic>=\u00a00.003). No statistically significant differences were seen in range of movement and overall hand function as reported by the<jats:styled-content style=\"fixed-case\">MHQ<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The severity of<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>is not milder in<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina than in<jats:styled-content style=\"fixed-case\">the UK<\/jats:styled-content>and the characteristics of hand involvement tend to be different. Clinicians should consider country\u2010specific differences in managing pain and delivering treatment. It would be helpful for a future study to investigate the<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>impact characteristics on a wider range of patients both from within<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina and from other populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12573","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T16:26:52Z","timestamp":1432744012000},"page":"1426-1436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of hand involvement in a comparative study of two early<scp>RA<\/scp>cohorts from the<scp>UK<\/scp>and<scp>C<\/scp>hina"],"prefix":"10.1111","volume":"20","author":[{"given":"Bowen","family":"Su","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences University of Southampton Southampton 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