{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:23:17Z","timestamp":1793391797197,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Comparison of ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) with non\u2010radiographic axial spondyloarthritis (nr\u2010axSpA) classified with the recent ASsessment of spondyloArthritis International Society (ASAS) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients &amp; Methods<\/jats:title><jats:p>This study included 288 patients clinically diagnosed as having spondyloarthritis (SpA) where a satisfactory radiograph of sacroiliac (S\u2010I) joints was available. The <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and the nr\u2010axSpA groups were compared for the various SpA\u2010related variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 288 axSpA patients, there were 187 with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>. Of the remaining 101 patients without radiographic sacroiliitis, S\u2010I joint magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) was available in 72; 54 of them showed active sacroiliitis thus classified as nr\u2010axSpA according to the <jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content> criteria. The remaining 18 patients with normal <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and the other 29 patients without <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> of the S\u2010I joints (total 47 patients), were classified as nr\u2010axSpA using the \u2018clinical arm\u2019 of the <jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content> criteria. On comparing the 187 <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> with 101 patients in the nr\u2010axSpA group, the <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> group showed significantly more males, longer disease duration, more axial symptoms at disease onset, higher Bath Ankylosing Spondylitis Metrology Index and more syndesmophytes. Biologicals were offered significantly more often to the <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> group but methotrexate as monotherapy or in combination with other disease\u2010modifying anti\u2010rheumatic drugs was offered more often in nr\u2010axSpA group. There was no statistically significant difference between <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and nr\u2010axSpA in other SpA parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The differences brought out between <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and nr\u2010axSpA groups show that they may not be the same disease. A prospective long\u2010term follow\u2010up of large cohorts may help in clarifying if nr\u2010axSpA is simply an early stage in the spectrum of SpA evolving into <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> over time or is there inherent difference between them.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12579","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T13:12:05Z","timestamp":1436879525000},"page":"736-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparison of patients with ankylosing spondylitis (<scp>AS<\/scp>) and non\u2010radiographic axial spondyloarthritis (nr\u2010axSpA) from a single rheumatology clinic in <scp>N<\/scp>ew <scp>D<\/scp>elhi"],"prefix":"10.1111","volume":"18","author":[{"given":"Anand N.","family":"Malaviya","sequence":"first","affiliation":[{"name":"\u2018A&amp;R Clinic\u2019 for Arthritis and Rheumatism New Delhi India"},{"name":"Department of Rheumatology ISIC Superspeciality Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Kalyani","sequence":"additional","affiliation":[{"name":"Department of Rheumatology ISIC Superspeciality Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopa","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Rheumatology ISIC Superspeciality Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Bhushan","family":"Gogia","sequence":"additional","affiliation":[{"name":"Department of Rheumatology ISIC Superspeciality Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0413-z"},{"key":"e_1_2_6_3_1","volume-title":"The Epidemiology of Chronic Rheumatism","author":"Kellgren JH","year":"1963"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-1049-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1227-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2010.01551.x"},{"key":"e_1_2_6_9_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_10_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_1","first-page":"1694","article-title":"Defining spinal mobility in ankylosing spondylitis (AS). 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