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Systemic therapy can be combined to intra\u2010articular treatments, including surgical synoviectomy, especially when monoarticular. Despite that, the synovial membrane commonly grows again with clinical relapse. Here, we report three case of patients diagnosed with <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content> of the knee who had an early relapse of the disease even after surgical synoviectomy. All of them underwent intra\u2010articular therapy with infliximab and subsequent synoviectomy to eradicate residual tissue. A complete remission of <jats:styled-content style=\"fixed-case\">CGT<\/jats:styled-content> was achieved without relapse occurring during the follow\u2010up. These preliminary data need to be confirmed by further clinical trials; however, intra\u2010articular therapy with infliximab might be deemed a potential option to treat <jats:styled-content style=\"fixed-case\">CGT<\/jats:styled-content> of a single joint.<\/jats:p>","DOI":"10.1111\/1756-185x.12585","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T15:27:59Z","timestamp":1435764479000},"page":"908-912","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Refractory knee giant cell tumor of the synovial membrane treated with intra\u2010articular injection of Infliximab: a case series and review of the literature"],"prefix":"10.1111","volume":"18","author":[{"given":"Emanuela","family":"Praino","sequence":"first","affiliation":[{"name":"Rheumatology Unit Medical School University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Lapadula","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Medical School University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crescenzio","family":"Scioscia","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Medical School University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Ingravallo","sequence":"additional","affiliation":[{"name":"Pathology Unit Medical School University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Covelli","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Medical School University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Medical School University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florenzo","family":"Iannone","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Medical School University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-006-0249-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B7.28927"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B3.30192"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.5.404"},{"key":"e_1_2_6_6_1","first-page":"185","article-title":"Cancer de la gaine des tendons","volume":"47","author":"Chassaignac M","year":"1852","journal-title":"Gaz Hop Civ Milit"},{"key":"e_1_2_6_7_1","first-page":"731","article-title":"Pigmented villonodular synovitis, bursitis and tenosynovitis","volume":"31","author":"Jaffe HL","year":"1941","journal-title":"Arch Pathol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251516"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003815102"},{"key":"e_1_2_6_10_1","first-page":"11","article-title":"Apoptosis resistance in pigmented villonodular synovitis","volume":"20","author":"Berger I","year":"2005","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740410009823"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.5858\/2000-124-1636-MGCTOS","article-title":"Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis) a histopathologic and\u00a0fluorescence in situ hybridization analysis of 2 cases with review of the literature","volume":"124","author":"Layfield LJ","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_13_1","first-page":"26","article-title":"Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction","volume":"18","author":"O'Keefe RJ","year":"1998","journal-title":"Iowa Orthop J"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025692"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu230"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2011.12.002"},{"key":"e_1_2_6_17_1","first-page":"1620","article-title":"Pigmented villonodular synovitis. 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