{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:06:04Z","timestamp":1781129164691,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eosinophilic granulomatosis with polyangiitis (<jats:styled-content style=\"fixed-case\">EGPA<\/jats:styled-content>) is characterized by eosinophilic vasculitis. Patients rarely present without asthma. Cases developing subarachnoid hemorrhage from central nervous system vasculitis are rarely reported. We report a 48\u2010year\u2010old woman with rapidly evolving and progressive multi\u2010system eosinophilic vasculitis in the absence of asthma. Tissue eosinophilia was apparent in a breast lump biopsy. Prior otitis media and prominent lymphoid tissue in the postnasal spaces hinted at otolaryngological disease. She had rapid disease progression with mononeuritis multiplex and eventually succumbed to complications of intracranial hemorrhage secondary to central nervous system vasculitis. This case demonstrates the diagnostic dilemma and treatment considerations in <jats:styled-content style=\"fixed-case\">EGPA<\/jats:styled-content> without asthma. It also raises the question if a reliable biomarker can aid diagnosis in atypical presentations of disease.<\/jats:p>","DOI":"10.1111\/1756-185x.12594","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T07:43:49Z","timestamp":1431330229000},"page":"2127-2131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Catastrophic subarachnoid hemorrhage in eosinophilic granulomatosis with polyangiitis without asthma"],"prefix":"10.1111","volume":"20","author":[{"given":"Matilda X. W.","family":"Lee","sequence":"first","affiliation":[{"name":"Internal Medicine Residency Singapore city Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gim Gee","family":"Teng","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University Medicine Cluster National University Health System Singapore city Singapore"},{"name":"Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore city Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangaraju Changal","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Health System Singapore city Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Y. 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