{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:03:25Z","timestamp":1774004605985,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Asan Institute for Life Science","award":["2014-463"],"award-info":[{"award-number":["2014-463"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hydronephrosis is a rare complication of systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>). Bladder and\/or gastrointestinal involvement in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> are associated with development of hydronephrosis, but the management and treatment outcomes of hydronephrosis are largely unknown. Therefore, we investigated the clinical manifestations and factors associated with the treatment response in patients with <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> complicated by hydronephrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis was performed of all 634 <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients who underwent computed tomography and\/or ultrasonography between January 1998 and December 2013. We reviewed the clinical characteristics and treatment outcomes of patients with <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>\u2010associated hydronephrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hydronephrosis was identified in 15 patients with <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> complicated by cystitis and\/or enteritis. All patients were treated initially with moderate to high doses of corticosteroids. A follow\u2010up imaging study showed that 11 (73.3%) of 15 patients experienced improvements in hydronephrosis, and urinary obstruction was resolved without urological intervention in the majority of these patients (8\/11, 72.7%). The four patients who experienced no improvement in hydronephrosis were older than those who responded to treatment (median age [interquartile range]; 43.0 [37.5\u201353.0] years <jats:italic>vs<\/jats:italic>. 28.0 [21.0\u201338.5] years; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.026). In addition, delayed treatment (\u2265\u00a01\u00a0month after onset of symptoms) with corticosteroids was more frequently observed in the non\u2010responding patients than in the responding patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that treatment with corticosteroids alone leads to favorable outcomes in patients with <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>\u2010associated hydronephrosis, except when treatment is delayed, particularly in elderly patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12599","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T03:42:07Z","timestamp":1438227727000},"page":"1317-1321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical outcomes of hydronephrosis in patients with systemic lupus erythematosus"],"prefix":"10.1111","volume":"19","author":[{"given":"Seokchan","family":"Hong","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Gil","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Hyeon","family":"Bae","sequence":"additional","affiliation":[{"name":"Division of 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