{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T07:40:08Z","timestamp":1717918808152},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prevalence of human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010B*27 among a healthy Kurdish population and in patients with ankylosing spondylitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prevalence of<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27 was investigated in 209 healthy donors recruited from the Kurdistan Region of Iraq, and in 41 diagnosed ankylosing spondylitis patients. The<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>statuses for the patients and healthy donors were determined by using the low\u2010resolution Olerup<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>typing kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that the prevalence of<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27 in healthy Kurdish donors was 3.8% (8\/209). While the prevalence of<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27 in patients with ankylosing spondylitis was 65.9% (27\/41 studied) with a<jats:italic>P\u2010<\/jats:italic>value of &lt;\u00a00.01. The relative risk of having the disease is 12 times higher in individuals with<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27 compared to those who do not have it. The male\u2010to\u2010female ratio was 5.8\u00a0:\u00a01 in<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27 positive patients. The disease onset is earlier in<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>From this study, we can conclude that the prevalence of<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27 among the Kurdish healthy population is 3.8% and there is a strong association between<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27 and ankylosing spondylitis patients in the Kurdistan Region of Iraq.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12605","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T17:09:46Z","timestamp":1432746586000},"page":"980-984","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of<scp>HLA<\/scp>\u2010B*27 with ankylosing spondylitis in Kurdish 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