{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T16:11:05Z","timestamp":1717949465179},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260461","81102255"],"award-info":[{"award-number":["81260461","81102255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the presence of autoantibodies (<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs) against interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201017A and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F and observe whether anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A or<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs are associated with disease activity in patients with early rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At present, 60 patients with<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>, 72 patients with osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>) and 61 healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) have been included in a database. Clinical assessment and laboratory data were recorded. We detected the titer of<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs against<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F using enzyme\u2010linked immunosorbent assay and analyzed the correlation of these<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs in patients with ERA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that the levels of<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs against<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F were significantly higher in<jats:styled-content style=\"fixed-case\">ERA OA<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>(<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). The level of<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs against<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F was correlated with Disease Activity Score\u201028 erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.0457) and<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>alone (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0032) in patients with<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>. In addition, in the<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>group, the level of C\u2010reactive protein and rheumatoid factor immunoglobulin M was lower in patients with<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs against<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F than patients without<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0247;<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0439). No significant correlation was observed between the clinical characteristics and level of<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs against<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in patients with<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>except<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>(<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0239).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs against<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F correlate with disease activity in patients with<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>. This evidence suggests that anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F<jats:styled-content style=\"fixed-case\">aA<\/jats:styled-content>bs may have a protective role in the pathogenesis of ERA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12618","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T14:42:55Z","timestamp":1434638575000},"page":"644-650","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated autoantibodies against interleukin\u201017F correlate with disease activity in patients with early rheumatoid arthritis"],"prefix":"10.1111","volume":"19","author":[{"given":"Lin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University Third Hospital Beijing 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