{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:45:23Z","timestamp":1769355923119,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Previous studies have shown that<jats:italic>C\u2010reactive protein<\/jats:italic>(<jats:italic>CRP<\/jats:italic>) gene polymorphism can be related to inflammatory changes. The present study aimed to examine the association between<jats:italic>CRP<\/jats:italic>gene polymorphism and clinical and laboratory findings in ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 80 patients, 40 with<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>and 40 controls, were included in the study. Diagnosis of<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>was made according to Assessment in<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>International Working Group criteria. Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Radiology Index scores were evaluated.<jats:italic>CRP<\/jats:italic>gene C, A and T alleles were evaluated and were determined using the analysis of melting curves after real time polymerase chain reaction. The odds ratios were calculated for all alleles and haploids of the<jats:italic>CRP<\/jats:italic>gene. We investigated the relationship between the<jats:italic>CRP<\/jats:italic>polymorphism and clinical and laboratory findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A, C, T allele frequencies in the control group were 15%, 57.5% and 27.5%. The allele frequencies in the<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>group were 38%, 68.8% and 26.2%. While C and T allele frequencies were shown to be similar in the two groups, A allele frequency was higher in the<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>group compared to the control group. The<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>wild allele was 42.5% in the control group and 47.5% in the<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>group (<jats:italic>P<\/jats:italic>= 1.0). Odds ratios for the C allele were 1.6, for the<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>haploid 1.2 and for the<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>haploid 3.7. Chest expansion and finger\u2010to\u2010ground distance was better in the<jats:italic>CRP<\/jats:italic>gene polymorphism group compared to the no polymorphism group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of the<jats:italic>CRP<\/jats:italic>gene<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>wild haploid and C allele in patients may indicate an increased risk for<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12619","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T17:39:35Z","timestamp":1445362775000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The relationship between C\u2010reactive protein rs3091244 polymorphism and ankylosing 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