{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:11:00Z","timestamp":1782601860045,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Weber\u2013Christian disease (<jats:styled-content style=\"fixed-case\">WCD<\/jats:styled-content>) is a chronic recurrent organ disease characterized by the formation of painful dense nodes in subcutaneous fat tissues, free from suppuration and accompanied by episodic temperature changes, chills and muscular pain. Sometimes it can involve the visceral organs. <jats:styled-content style=\"fixed-case\">WCD<\/jats:styled-content> often relapses during irregular intervals. It is a rare autoimmune inflammatory disorder of subcutaneous adipose tissue. However, lung involvement in <jats:styled-content style=\"fixed-case\">WCD<\/jats:styled-content> is rare. Here we report a man presenting with lung nodules. He was diagnosed as having <jats:styled-content style=\"fixed-case\">WCD<\/jats:styled-content> and successfully treated by corticosteroid and immonosuppressive agents. A 53\u2010year\u2010old male presented with a 2.5\u2010year history of painful subcutaneous nodules on his trunk and limbs, accompanied by fever, night sweats, fatigue and malaise. A skin biopsy showed fat degeneration with foamy cells and infiltration of mononuclear cells. He was diagnosed as panniculitis and effectively treated by corticosteroid therapy at first. However, symptoms relapsed when the dosage of corticosteroid was tapered, and multiple lung nodules were found with the symptom of dyspnea in chest computed tomography scan during the follow\u2010up period. Histological examination of the biopsy specimens from the lung was compatible with panniculitis change in the subcutanous nodule. Combination therapy of corticosteroid with cyclophosphamide was effective during the following 27\u00a0months.<\/jats:p>","DOI":"10.1111\/1756-185x.12620","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T03:45:54Z","timestamp":1438227954000},"page":"573-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Weber\u2010<scp>C<\/scp>hristian disease presenting with lung nodules dramatically improved with corticosteroid therapy: one case report and literature review"],"prefix":"10.1111","volume":"21","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan lan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"41","article-title":"Skin lesions depicting a systemic disease. Weber\u2010Christian disease","volume":"69","author":"Moonen LA","year":"2011","journal-title":"Neth J Med"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-18"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002960050100"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.38.612"},{"key":"e_1_2_4_6_1","first-page":"313","article-title":"A fatal case of Weber\u2010Christian disease (relapsing, febrile, nodular, non\u2010suppurative panniculitis)","volume":"31","author":"Bjornstad RT","year":"1951","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1925.tb10003.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1928.00020020026004"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-49-3-687"},{"key":"e_1_2_4_10_1","first-page":"29","article-title":"A case of Weber\u2010Christian disease, revealing cavitated nodule in the lung (author's transl)","volume":"14","author":"Matsuzaki M","year":"1976","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"e_1_2_4_11_1","first-page":"174","article-title":"Pulmonary radiographic findings in a case of febrile, relapsing, nonsuppurative panniculitis (Weber\u2010Christian disease)","volume":"43","author":"Federman Q","year":"1976","journal-title":"Mt Sinai J Med"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21874"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00332.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00331.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20502"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:54:14Z","timestamp":1695473654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/1756-185X.12620"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12620","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,29]]},"assertion":[{"value":"2015-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}