{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:34:43Z","timestamp":1782369283056,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Minist\u00e9rio da Sa\u00fade\/Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia (PPSUS\/FAPESB)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p><jats:italic>Strongyloides stercoralis<\/jats:italic> infection is usually chronic and asymptomatic and may persist undiagnosed for decades. However, in immunocompromised individuals, the infection can cause hyperinfection and dissemination. Therefore, early diagnosis is essential to prevent severe forms of strongyloidiasis. The aims of this study were: (i) to evaluate the frequency of <jats:italic>S.\u00a0stercoralis<\/jats:italic> infection in patients with systemic lupus erythematous (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) and (ii) to estimate specific immunoglobulins G (IgG) and E (IgE) production using an enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients treated with prophylactic anthelmintic therapy were evaluated using the spontaneous sedimentation (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>), Baermann\u2013Moraes (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) and agar plate culture (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>) methods. Serum anti\u2010<jats:italic>S.\u00a0stercoralis<\/jats:italic> IgG and IgE antibodies were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using parasitological methods, the frequency of intestinal parasites was 10.7%, whereas the frequency of <jats:italic>S.\u00a0stercoralis<\/jats:italic> infection was 1.3%. The sensitivity of the <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> to detect anti\u2010<jats:italic>S.\u00a0stercoralis<\/jats:italic> IgG and IgE was 80% and 76.9%, respectively. Both assays presented the same specificity of 96.7%. The frequency of anti\u2010<jats:italic>S.\u00a0stercoralis<\/jats:italic> IgG and IgE was 16% and 28%, respectively. Six patients were positive for both antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diagnostic approaches using high\u2010sensitivity parasitological methods and the detection of specific antibodies are essential for the diagnosis of strongyloidiasis in immunocompromised patients. Early detection of infection can alter the course of the disease via appropriate treatment, preventing the occurrence of severe strongyloidiasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12644","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T13:57:07Z","timestamp":1439215027000},"page":"700-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Strongyloides stercoralis<\/i> infection in patients with systemic lupus erythematosus: diagnosis and prevention of severe strongyloidiasis"],"prefix":"10.1111","volume":"19","author":[{"given":"Joelma Nascimento","family":"de Souza","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabete De 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