{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:18:33Z","timestamp":1791389913427,"version":"4.3.3"},"reference-count":66,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyze the clinical features, outcomes and prognosis of neonatal lupus erythematosus (<jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content>) in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We reviewed 12 <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content> cases at the Peking Union Medical College Hospital and compared the data with 111 cases reported in China between 1990 and 2014. The Chinese medical journal search engines used in this study were Wanfang.data and Science China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No gender dominance in <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content> incidence was found. Cutaneous lesions were present in more than 96% of patients, while cardiac, hematological and hepatobiliary manifestations were seen in 12.61%, 45.53% and 17.89% of cases, respectively. Congenital heart block (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) tended to be more persistent, with two cases showing <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> for 1\u00a0year and three cases persisting for 7\u201310\u00a0years. In this study more than 90% of mothers were anti\u2010Sj\u00f6gren's syndrome A positive, and 65.04% were asymptomatic prior to the pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that clinicians, especially dermatologists, in China should improve their recognition of this disease to avoid misdiagnosis, and more attention should be paid to the follow\u2010up of <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content> patients and their asymptomatic mothers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12652","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T13:12:37Z","timestamp":1436879557000},"page":"761-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Neonatal lupus erythematosus: a review of 123 cases in 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