{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T11:36:08Z","timestamp":1769340968383,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Leprosy patients may present several osteoarticular complaints, which require further evaluation of inflammatory diseases, such as rheumatoid arthritis (RA<\/jats:styled-content>). Therefore, an adequate clinical assessment in addition to testing for rheumatoid factors (RF<\/jats:styled-content>) and anticyclic citrullinated peptide antibodies (anti\u2010CCP<\/jats:styled-content>), can be useful in order to establish the correct diagnosis.<\/jats:p><\/jats:sec>Method<\/jats:title>In this study, the relation of RF<\/jats:styled-content> and anti\u2010CCP<\/jats:styled-content> with rheumatological manifestations was evaluated in 97 leprosy patients from Southern Brazil. The results were compared to RA<\/jats:styled-content> patients and healthy controls from the same geographical area and ethnic background.<\/jats:p><\/jats:sec>Results<\/jats:title>Neuropathy was observed in 71.1% and arthritis in 35.1% of the leprosy patients. A high frequency of RF<\/jats:styled-content> positivity was observed among the leprosy patients (41.2%, 40\/97), with RF<\/jats:styled-content> immunoglobulin A (IgA) significantly associated with arthritis (OR<\/jats:styled-content>\u00a0=\u00a07.9, 95% CI<\/jats:styled-content>\u00a0=\u00a01.5\u201340.6 P\u00a0<\/jats:italic>=\u00a00.008). Anti\u2010CCP<\/jats:styled-content> was observed in 9.3% (9\/97) of the patients, with anti\u2010CCP<\/jats:styled-content>2 being the most frequent subtype. Only 4.1% (4\/97) of the patients were RF<\/jats:styled-content> and anti\u2010CCP<\/jats:styled-content> concomitantly positive. RF<\/jats:styled-content> IgM showed a significant association with leprosy when compared to healthy controls (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001) whereas for anti\u2010CCP<\/jats:styled-content>2 no significant results were observed (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.0585). However, both biomarkers showed a strong association with RA<\/jats:styled-content> when compared to leprosy in patients from the same geographical area and ethnic background (anti\u2010CCP<\/jats:styled-content>2 OR<\/jats:styled-content>\u00a0=\u00a038.6; 95% CI<\/jats:styled-content>\u00a0=\u00a016.49\u201390.26; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001 and RF<\/jats:styled-content> IgM OR<\/jats:styled-content>\u00a0=\u00a04.51; 95% CI<\/jats:styled-content>\u00a0=\u00a02.62\u20137.77; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Due to the similarity of some rheumatological manifestations in leprosy with other inflammatory diseases, such as RA<\/jats:styled-content>, clinical and laboratorial evaluation of affected patients must be carefully assessed in order to achieve proper diagnosis and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12668","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T19:45:27Z","timestamp":1438890327000},"page":"1024-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of rheumatoid factor and anti\u2010citrullinated peptide antibodies in relation to rheumatological manifestations in patients with leprosy from Southern Brazil"],"prefix":"10.1111","volume":"19","author":[{"given":"Carla Fontoura","family":"Dionello","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia Departamento de Patologia M\u00e9dica Clinical Hospital of Federal University of Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley Ramos","family":"Rosa Utiyama","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia Departamento de Patologia M\u00e9dica Clinical Hospital of Federal University of Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o C\u00e9zar","family":"Radominski","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna Clinical Hospital of Federal University of Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewalda","family":"Stahlke","sequence":"additional","affiliation":[{"name":"Setor de Dermatologia Centro Regional de Especialidades Metropolitano de Curitiba Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Servio Tulio","family":"Stinghen","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia Departamento de Patologia M\u00e9dica Clinical Hospital of Federal University of Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iara Jose","family":"de 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