{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:54:41Z","timestamp":1777463681886,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Immunoglobulin\u2010G4 (IgG4)\u2010related tubulo\u2010interstitial nephritis (IgG4<jats:styled-content style=\"fixed-case\">TIN<\/jats:styled-content>) could be the first presentation of IgG4\u2010related systemic disease. Most of the data is from the West or Japan and retrospective, with good patient outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was carried out from April 2011 to July 2013. We report a prospective follow\u2010up of 11 patients who presented with renal dysfunction and had histological diagnosis of IgG4<jats:styled-content style=\"fixed-case\">TIN<\/jats:styled-content> followed for a minimum period of 1\u00a0year or until end\u2010stage renal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IgG4<jats:styled-content style=\"fixed-case\">TIN<\/jats:styled-content> constituted 0.28% of total renal biopsies and 6.5% of all tubulointerstitial nephritis. Patient ages ranged between 21 and 71\u00a0years with a male predominance. All the patients had renal dysfunction at presentation with a mean serum creatinine of 5.12\u00a0mg\/dL. Proteinuria was subnephrotic except when there was coexisting membranous glomerulonephritis (36.4%). The mean 24\u2010h urine protien excretion was 1.8\u00a0g. Serum IgG4 levels were elevated in 10 (90.9%) patients. Ten (90.9%) patients had renomegaly and one (9.1%) had focal renal mass. Extra\u2010renal manifestations were present in seven (63.6%). Renal histology showed pattern A in five (45.5%), pattern B in four (36.3%) and pattern C in two (18.1%) patients. All but one patient (90.9%) received immunosuppressive therapy. Four (36.3%) achieved complete remission and three (27.2%) progressed to end stage renal disease. Two patients died due to infections while on steroid therapy. One patient with a mass had end stage renal disease for 12\u00a0months and did not improve with steroid therapy, and one (pattern C) had progressive chronic kidney disease on follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IgG4<jats:styled-content style=\"fixed-case\">TIN<\/jats:styled-content> in an Indian cohort most often presents with rapidly progressive renal failure and less often has extra\u2010renal organ involvement. On follow\u2010up, patients can experience a more aggressive course with progression to end stage renal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12675","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T12:20:29Z","timestamp":1471609229000},"page":"721-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["IgG4\u2010related tubulointerstitial nephritis: A prospective analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Ritambhra","family":"Nada","sequence":"first","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research Chandigarh 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