{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:35:50Z","timestamp":1787236550302,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chonnam National University Hospital Biomedical Research Institute","award":["CRI10049-1"],"award-info":[{"award-number":["CRI10049-1"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n To investigate whether patients with Sj\u00f6gren's syndrome (\n SS<\/jats:styled-content>\n ) can be distinguished based on the positivity of anti\u2010centromere antibody (\n ACA<\/jats:styled-content>\n ), and if so, whether the subgroups differ in their clinical and laboratory features.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eleven patients with\n ACA<\/jats:styled-content>\n \u2010positive and 71 patients\n ACA<\/jats:styled-content>\n \u2010negative\n SS<\/jats:styled-content>\n were examined. All patients had minor salivary gland biopsy; sociodemographic data, glandular and extraglandular manifestations, and laboratory findings, including autoantibodies, complement and immunoglobulin levels, were analyzed. European League Against Rheumatism\n SS<\/jats:styled-content>\n disease activity index (\n ESSDAI<\/jats:styled-content>\n ) and\n SS<\/jats:styled-content>\n disease damage index (\n SSDDI<\/jats:styled-content>\n ) were also measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The prevalence of\n ACA<\/jats:styled-content>\n among\n SS<\/jats:styled-content>\n patients was 13.4%.\n ACA<\/jats:styled-content>\n \u2010positive\n SS<\/jats:styled-content>\n patients had a higher prevalence of Raynaud's phenomenon, sclerodactyly and autoimmune thyroiditis and a lower prevalence of anti\u2010\n SSA<\/jats:styled-content>\n \/Ro and anti\u2010\n SSB<\/jats:styled-content>\n \/La antibodies compared to\n ACA<\/jats:styled-content>\n \u2010negative patients. Disease activity was higher in\n ACA<\/jats:styled-content>\n \u2010positive patients than in\n ACA<\/jats:styled-content>\n \u2010negative patients, but the damage index did not differ between the two groups. None of the patients who originally had\n ACA<\/jats:styled-content>\n evolved to having full\u2010blown systemic sclerosis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Patients with\n SS<\/jats:styled-content>\n who have\n ACA<\/jats:styled-content>\n differ from classic\n SS<\/jats:styled-content>\n patients in several clinical and laboratory parameters.\n ACA<\/jats:styled-content>\n should be considered one of the pathogenically relevant autoantibodies for\n SS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.12684","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T17:05:12Z","timestamp":1436893512000},"page":"776-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Anti\u2010centromere antibody\u2010positive Sj\u00f6gren's syndrome: A distinct clinical subgroup?"],"prefix":"10.1111","volume":"18","author":[{"given":"Kyung\u2010Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Chonnam National University Medical School & Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hyoun","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Chonnam National University Medical School & Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Chonnam National University Medical School & Hospital Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Wen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine 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