{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:10:33Z","timestamp":1793686233860,"version":"4.5.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This is an analysis of adult Behcet's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) in Iran, from the Iran Registry of 7187 <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients, gathered from 1975 to 2014, among which 6075 were adults (84.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Patients were seen by a multidisciplinary team of experts. The diagnosis was by expert opinion, not by any specific classification\/diagnosis criteria. However, 96.8% of them were classified by the International Criteria for Behcet's Disease (<jats:styled-content style=\"fixed-case\">ICBD<\/jats:styled-content>). Adult <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>s were patients who had their first manifestation at the age of 16 or later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Males constituted 56% (male\/female ratio 1.3\/1). The mean age at onset was 28.3\u00a0\u00b1\u00a08.7, mean duration 10.8\u00a0\u00b1\u00a08.2, and mean follow\u2010up 5.0\u00a0\u00b1\u00a06.3. Oral aphthosis was seen in 97.5%, genital aphthosis 65.7%, skin manifestations 64.6% (pseudofolliculitis 53.2%, erythema nodosum 23.9%), ocular manifestations 58.1% (anterior uveitis 41.1%, posterior uveitis 45%, retinal vasculitis 33.6%, cataract 24.4%), joint manifestations 39.4% (arthralgia 18.9%, monoarthritis 9.1%, oligoarthritis 17.8%, ankyloing spondylitis 2%), gastrointestinal manifestations 7% (gastroduodenitis 2.3%, peptic ulcer 1.2%, diarrhea 2.1%, rectorrhagia 1.0%, abdominal pain\u2010nausea 1.8%), neurological manifestations 10.6% (central 3.7%, peripheral 0.3%, headache 7.6%), vessel involvement (large vessel 1.7% with large vein thrombosis 1.1% and arterial involvement 0.7%, phlebitis 6.6%, superficial phlebitis 2.3%), epididymitis 4.6%, pulmonary manifestations 1% and cardiac manifestations 0.6%. Positive pathergy test was seen in 52.3%, human leukocyte antigen (HLA)\u2010B5 in 54%, HLA\u2010B51 in 48.9%, and high erythrocyte sedimentation rate in 52.8% of patients. By International Study Group (ISG) criteria 77.9% were classified, compared to ICBD revised criteria with 96.9%. The specificity of ISG was 99.2% and ICBD 97.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results are near the nationwide surveys from Japan, China, Korea and Germany.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12691","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T13:56:49Z","timestamp":1439215009000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Adult Behcet's disease in Iran: analysis of 6075 patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Fereydoun","family":"Davatchi","sequence":"first","affiliation":[{"name":"Behcet's Disease Unit Rheumatology Research Center Tehran University of Medical Sciences Shariati Hospital Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheyda","family":"Chams\u2010Davatchi","sequence":"additional","affiliation":[{"name":"Behcet's Disease Unit 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