{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:39:53Z","timestamp":1776127193431,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health and Welfare, Republic of Korea","award":["A120960"],"award-info":[{"award-number":["A120960"]}]},{"name":"Hallym University Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The Disease Activity Score based on 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) has been widely used in clinical practice and research studies of rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). The objective of this study was to evaluate the discordance in the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 based on the erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>) versus C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) levels in Korean patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From August to December 2011, 540 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> who visited two rheumatology clinics affiliated with Hallym University (Korea) and had at least one <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 evaluation were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the included patients was 53\u00a0years, and 82% were female. The mean duration of disease was 32.9\u00a0\u00b1\u00a041.2\u00a0months. The mean <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> was higher than the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (3.65 <jats:italic>vs<\/jats:italic>. 3.44; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). In the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> group, 126 patients (23.3%) satisfied the criteria for remission versus 134 (24.8%) in the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> group. High disease activity was determined in 80 (14.8%) patients in the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> group and in 43 (8.0%) in the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> group. A comparison of the two groups with respect to four <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 disease activity categories showed agreement in 344 patients (63.7%; \u03ba\u00a0=\u00a00.45). In classifying patients as European League Against Rheumatism (<jats:styled-content style=\"fixed-case\">EULAR<\/jats:styled-content>) responders, agreement between the two methods was shown in 56 patients (71.8%; \u03ba\u00a0=\u00a00.76). When disagreements between the two scores occurred, more patients had a better <jats:styled-content style=\"fixed-case\">EULAR<\/jats:styled-content> response based on the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> than on the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (19.2% <jats:italic>vs<\/jats:italic>. 8.9%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The discordance between the <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>\u2010based and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\u2010based <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 could affect clinical treatment decisions for patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12698","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T10:42:48Z","timestamp":1437561768000},"page":"1278-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of the disease activity score using the erythrocyte sedimentation rate and C\u2010reactive protein levels in Koreans with rheumatoid arthritis"],"prefix":"10.1111","volume":"19","author":[{"given":"Kyeong Min","family":"Son","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon Kangwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hallym University Sacred Heart Hospital Pyongchon Anyang Kyunggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hallym University Sacred Heart Hospital Pyongchon Anyang Kyunggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Mi","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hallym University Sacred Heart Hospital Pyongchon Anyang Kyunggi Korea"},{"name":"Institute for Skeletal Aging Hallym University College of Medicine Chuncheon Kangwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Il","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hallym University Sacred Heart Hospital Pyongchon Anyang Kyunggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hallym University Sacred Heart Hospital Pyongchon Anyang Kyunggi Korea"},{"name":"Institute for Skeletal Aging Hallym University College of Medicine Chuncheon Kangwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2010.25.1.1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123919"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063834"},{"key":"e_1_2_8_6_1","first-page":"151","article-title":"Disease activity scores using C\u2010reactive protein: CRP may replace ESR in the assessment of RA 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