{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:36:56Z","timestamp":1781498216230,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare hand osteoarthritis (<jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content>) subtypes and to examine possible links with local bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty\u2010five patients with erosive hand osteoarthritis (<jats:styled-content style=\"fixed-case\">EHOA<\/jats:styled-content>) and 21 patients with nodal hand osteoarthritis (<jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>) fulfilling American College of Rheumatology criteria for <jats:styled-content style=\"fixed-case\">HOA<\/jats:styled-content> were evaluated. Subjects showing at least two erosions of the interphalangeal joints were assigned to the <jats:styled-content style=\"fixed-case\">EHOA<\/jats:styled-content> group; the others were considered <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>. Disease duration, number of active joints and radiological scores were assessed. All patients and 174 controls underwent phalangeal radiographic absorptiometry (<jats:styled-content style=\"fixed-case\">pRA<\/jats:styled-content>) of the middle phalanges of the non\u2010dominant hand to assess <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>,<jats:italic> T<\/jats:italic>\u2010 and <jats:italic>Z<\/jats:italic>\u2010scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> was higher in <jats:styled-content style=\"fixed-case\">EHOA<\/jats:styled-content> with respect to <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content> and controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.05); <jats:italic>T<\/jats:italic>\u2010 and <jats:italic>Z<\/jats:italic>\u2010scores were significantly higher in <jats:styled-content style=\"fixed-case\">EHOA<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01 and <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Values suggestive of osteopenia were found in 32% of <jats:styled-content style=\"fixed-case\">EHOA<\/jats:styled-content> and 22% of <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content> patients, and in 44% of controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.05 <jats:styled-content style=\"fixed-case\">EHOA <\/jats:styled-content><jats:italic>vs<\/jats:italic>. <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>); a <jats:italic>T<\/jats:italic>\u2010score &lt;\u00a0\u22122.5 standard deviations was present in 15% of <jats:styled-content style=\"fixed-case\">EHOA<\/jats:styled-content> and 28% of <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content> patients, and in 21% of controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.05 <jats:styled-content style=\"fixed-case\">EHOA <\/jats:styled-content><jats:italic>vs<\/jats:italic>. <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Phalangeal <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> was higher in <jats:styled-content style=\"fixed-case\">EHOA<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content> and controls. This characteristic could potentially be exploited to differentiate the two hand <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12709","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T21:08:01Z","timestamp":1436908081000},"page":"954-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The controversial relationship between osteoarthritis and osteoporosis: an update on hand subtypes"],"prefix":"10.1111","volume":"19","author":[{"given":"Roberta","family":"Ramonda","sequence":"first","affiliation":[{"name":"Rheumatology Unit Department of Medicine DIMED University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Sartori","sequence":"additional","affiliation":[{"name":"Clinica Medica I Department of Medicine DIMED University of Padova Padova 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