{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:38:23Z","timestamp":1779338303222,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Fibromyalgia syndrome (<jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>) is an extremely rare complication of neurocognitive disorders (<jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>s). We experienced seven such cases, and we discuss their clinical manifestation and pathomechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven patients with <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> as a complication of <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content> were enrolled. We used the patients' medical records to identify clinical manifestations and obtain experimental data, such as pain questionnaire scores, cognitive tests, genetics and radiological imaging of the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The seven patients were clinically diagnosed with frontotemporal <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>3) or Alzheimer's disease (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4). No patient presented with any organic disorder that would explain their chronic pain. Through their courses, they experienced refractory widespread pain continuously despite analgesics. Brain magnetic resonance\u00a0imaging revealed moderate or severe atrophic changes in the temporal lobes and hippocampus. Three\u2010dimensional stereotactic surface projection (3D\u2010<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content>) analysis of brain single photon emission computed tomography (<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>), indicated severe hypoperfusion on the right side of the medial temporal lobe, both sides of the anterior corpus callosum, anterior cingulate gyrus, and primary sensory area. Genetic analysis uncovered no pathogenic mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neurodegenerative disorders are rarely complicated by <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content>, which is associated with relatively severe pain. Central sensitization may be a possible risk factor of widespread pain in elderly patients with <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12734","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T14:37:44Z","timestamp":1441895864000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series"],"prefix":"10.1111","volume":"19","author":[{"given":"Kenya","family":"Nishioka","sequence":"first","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michimasa","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiology Juntendo University School of Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine Tokyo Medical University Tokyo 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