{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:00:36Z","timestamp":1788091236905,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T00:00:00Z","timestamp":1442620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pathogenesis of idiopathic inflammatory myositis (IIM) involves strong interactions between dendritic cells (DCs), activated Th1 and Th17 cells, B cells, muscle cells, genes and environment. Local maturation of DCs permit the activation and polarization of CD4+ T cells into T<jats:sub>H<\/jats:sub>1 and T<jats:sub>H<\/jats:sub>17 that play a key role in maintaining chronic muscle inflammation. T\u2010cell mediated myocytotoxicity promotes the liberation of specific muscle autoantigens from regenerating muscle cells with production of myositis\u2010specific autoantibodies. Type I interferon signature is a key characteristic of IIM. Type I IFN that can be induced by immune complexes containing myositis\u2010specific autoantibodies is produced by scattered plasmacytoid DCs but also by muscle cells particularly regenerating muscle cells. These immature muscle precursors appear to be critical in the pathogenesis of IIM as they up\u2010regulate muscle autoantigens, type I IFN, HLA class I antigens and TLR3\u20107, all together involved in maintaining chronic muscle inflammation. In addition to the role of immune and muscle cells, genome\u2010wide association studies have confirmed the importance of several MHC and non\u2010MHC genes in IIM. Environmental factors can contribute to the pathogenesis of IIM. In sIBM, distinct features suggest both degenerative and inflammatory processes. In addition to our better understanding of the pathogenesis, identify molecular pathway leads to consider new targeted therapies including cytokine inhibition, B\u2010cell and T\u2010cell costimulation blockade, type I IFN neutralization or inhibition of the ubiquitin proteasome pathway.<\/jats:p>","DOI":"10.1111\/1756-185x.12736","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T10:59:22Z","timestamp":1442660362000},"page":"818-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Idiopathic inflammatory myopathies: from immunopathogenesis to new therapeutic targets"],"prefix":"10.1111","volume":"18","author":[{"given":"Syed A.","family":"Haq","sequence":"first","affiliation":[{"name":"BSM Medical University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tournadre","sequence":"additional","affiliation":[{"name":"Rheumatology department CHU Clermont\u2010Ferrand and UMR 1019 INRA\/ University of Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.02.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000173991.74008.b0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.02.013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22558"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20649"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11428"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33350"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27465"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2075-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830241114"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03180.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(03)00032-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.095984"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290509"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200495"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22790"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020186"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803688"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939399"},{"key":"e_1_2_10_21_1","first-page":"S86","article-title":"Persisting CD28(null) T cells, but not regulatory T cells, in muscle tissue of myositis patients after immunosuppressive therapy","volume":"63","author":"Loell IM","year":"2011","journal-title":"Arthritis Rheum"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.547"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3275"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22860"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22928"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3377"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38292"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200839"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90128-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821f440a"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041367"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30156"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21103"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38180"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.222"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38137"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01398.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000189818.63141.8c"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000217525.82287.eb"},{"issue":"9","key":"e_1_2_10_41_1","first-page":"1","article-title":"HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population","volume":"14","author":"Gao X","year":"2014","journal-title":"BMC Dermatol"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34657"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21671"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.05.003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2011.01596.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200182"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201849"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2011.01669.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160207"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187124.92826.20"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23840"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1474-9728.2003.00034.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21103"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.08.021"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31826183c8"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20584"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21386"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0102-5"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.04.007"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22477"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202857"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.08.007"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker152"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37754"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker305"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu024"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38270"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp104"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu484"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2507-4"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202794"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12736","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:12:39Z","timestamp":1696378359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,19]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/1756-185X.12736"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12736","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,19]]},"assertion":[{"value":"2015-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}