{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:15:20Z","timestamp":1695798920613},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008377","name":"Handok","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The prognosis of pulmonary hypertension (PH<\/jats:styled-content>) in systemic sclerosis (SSC<\/jats:styled-content>) and in systemic lupus erythematosus (SLE<\/jats:styled-content>) is different. According to the guidelines, right heart catheterization (RHC<\/jats:styled-content>) is necessary in pulmonary arterial hypertension (PAH<\/jats:styled-content>) associated with connective tissue diseases (CTD<\/jats:styled-content>). However, there is little supporting evidence. Therefore, we attempted to determine the necessity for RHC<\/jats:styled-content> and the causes of differences in prognosis of PH<\/jats:styled-content> by comparing SSC<\/jats:styled-content> to SLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The inclusion criteria were all patients with SSC<\/jats:styled-content> or SLE<\/jats:styled-content> with exertional dyspnea. Echocardiography and carotid Doppler ultrasound were performed.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010three patients with SSC<\/jats:styled-content> and 23 with SLE<\/jats:styled-content> participated in this study. There was no difference in the right ventricular systolic pressure (RVSP<\/jats:styled-content>) between SSC<\/jats:styled-content> and SLE<\/jats:styled-content> (33.0\u00a0mmHg, range 25.3\u201341.7\u00a0mmHg vs<\/jats:italic>. 32.4\u00a0mmHg, range 27.0\u201337.7\u00a0mmHg; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.835). In multiple linear regression analysis, the ratio of peak tricuspid regurgitant velocity to right ventricular outflow tract time\u2010velocity integral, which represents pulmonary vascular resistance (PVR<\/jats:styled-content>), was correlated with RVSP<\/jats:styled-content> in SSC<\/jats:styled-content> (r<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.928, \u03b2\u00a0=\u00a00.362, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003), and the independent predictor of increased RVSP<\/jats:styled-content> was the ratio of early diastolic transmitral filling velocity to early diastolic septal mitral annular velocity, which represents diastolic dysfunction in SLE<\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.806, \u03b2\u00a0=\u00a00.803, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.023).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>PVR<\/jats:styled-content> was an important cause of PH<\/jats:styled-content> in SSC<\/jats:styled-content>. Left ventricular dysfunction was an important cause of PH<\/jats:styled-content> in SLE<\/jats:styled-content>. Thus, these findings demonstrate the necessity for RHC<\/jats:styled-content> and differences in prognosis of PH<\/jats:styled-content> in CTD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12769","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T10:14:49Z","timestamp":1444212889000},"page":"65-73","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Determining the necessity for right heart catheterization in pulmonary hypertension associated with connective tissue diseases assessed by echocardiography"],"prefix":"10.1111","volume":"19","author":[{"given":"Joon Hyouk","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiology Internal Medicine Jeju National University Hospital Jeju 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