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With better understanding of underlying immunopathogenesis, effective targeted therapies are available which improve symptoms, quality of life and possibly slow the radiographic progression. There has been a growing interest in the discovery of biomarkers for defining various aspects of disease assessment and management in Ankylosing Spondylitis. The C\u2010reactive protein and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27 are most commonly used biomarkers. 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