{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:54:41Z","timestamp":1783515281373,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T00:00:00Z","timestamp":1453420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the serum transforming growth factor beta 1 (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b21) and fetuin\u2010A levels, and determined the relationships between these biomarkers and disease activity, mobility and radiologic progression in patients with spondyloarthropathy (SpA) and rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study included 55 patients with SpA and 38 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, together with 28 healthy subjects. In <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients, we assessed disease activity using the Bath Ankylosing Spondylitis Disease Activity Index (<jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content>), functional ability using the Bath Ankylosing Spondylitis Functional Index (<jats:styled-content style=\"fixed-case\">BASFI<\/jats:styled-content>), and mobility using the Bath Ankylosing Spondylitis Metrology Index (<jats:styled-content style=\"fixed-case\">BASMI<\/jats:styled-content>), radiologic progression using the Bath Ankylosing Spondylitis Radiology Index (<jats:styled-content style=\"fixed-case\">BASRI<\/jats:styled-content>). Serum fetuin\u2010A and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b21 were determined using enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) equipment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetuin\u2010A was significantly higher in the axial SpA and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> groups than in healthy subjects (<jats:italic>P<\/jats:italic> &lt; 0.01). Serum <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b21 and fetuin\u2010A levels were similar in the peripheral SpA group and in healthy subjects. A significant positive correlation was found between the fetuin\u2010A and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b21 levels in the axial SpA, peripheral SpA, and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> groups (<jats:italic>r<\/jats:italic> = 0.293, <jats:italic>P<\/jats:italic> = 0.009; <jats:italic>r<\/jats:italic> = 0.215, <jats:italic>P<\/jats:italic> = 0.04; <jats:italic>r<\/jats:italic> = 0.223, <jats:italic>P<\/jats:italic> = 0.05, respectively). Significant correlations were found between fetuin\u2010A and the <jats:styled-content style=\"fixed-case\">BASMI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BASRI<\/jats:styled-content> values in the axial SpA patients (<jats:italic>r<\/jats:italic> = 0.444, <jats:italic>P<\/jats:italic> = 0.031; <jats:italic>r<\/jats:italic> = 0.486, <jats:italic>P<\/jats:italic> &lt; 0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that Fetuin\u2010A may be one of the steps that can be active in disease progression in axial SpA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12791","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T16:19:55Z","timestamp":1453479595000},"page":"2020-2027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of fetuin\u2010A and transforming growth factor beta 1 levels in patients with spondyloarthropathies and rheumatoid arthritis"],"prefix":"10.1111","volume":"20","author":[{"given":"Halil","family":"Harman","sequence":"first","affiliation":[{"name":"Divison of Rheumatology Department of Pysical Medicine and Rehabilitation Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Tekeo\u011flu","sequence":"additional","affiliation":[{"name":"Divison of Rheumatology Department of Pysical Medicine and Rehabilitation Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6n\u00fcl","family":"G\u00fcrol","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Serdar","family":"Sa\u011f","sequence":"additional","affiliation":[{"name":"Divison of Rheumatology Department of Pysical Medicine and Rehabilitation Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Karake\u00e7e","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130hsan Hakk\u0131","family":"\u00c7\u0130ft\u00e7\u0130","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Kamanl\u0131","sequence":"additional","affiliation":[{"name":"Divison of Rheumatology Department of Pysical Medicine and Rehabilitation Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"Nas","sequence":"additional","affiliation":[{"name":"Divison of Rheumatology Department of Pysical Medicine and Rehabilitation Sakarya University Faculty of Medicine Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24406"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.55"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234260"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1117"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(10)07"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2009.01448.x"},{"issue":"7","key":"e_1_2_6_8_1","first-page":"515","article-title":"[Alpha 2 HS\u2010glycoprotein in rheumatoid arthritis. 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