{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:28:09Z","timestamp":1792412889176,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate the relationship between hematological markers and disease activity in patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study was designed and performed in the Department of Rheumatology of the Sakarya University Faculty of Medicine. In total, 102 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> were retrospectively enrolled. We used the Disease Activity Score of 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) instrument to evaluate disease activity. Laboratory assessments included complete blood cell counts, measurement of erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>) and assessment of C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) level. Exclusion criteria included active infection and\/or the presence of any hematological, cardiovascular or metabolic disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the neutrophil lymphocyte ratio (<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) and mean platelet volume (<jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content>) varied by disease activity status. <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> values correlated positively with the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 scores of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients. Especially, higher <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> values (3.92 \u00b1 0.31) were evident in the group exhibiting high\u2010level disease activity, whereas the <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> values were lowest (7.11 \u00b1 0.91 <jats:styled-content style=\"fixed-case\">fL<\/jats:styled-content>) in this group. Additionally, no significant difference was evident between <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 scores and platelet distribution width (<jats:styled-content style=\"fixed-case\">PDW<\/jats:styled-content>) values in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = \u22120.055, <jats:italic>P<\/jats:italic> = 0.124).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that the <jats:styled-content style=\"fixed-case\">MPV<\/jats:styled-content> value may serve as a marker of the absence of acute\u2010phase disease, and the <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> level as a marker of the presence of such disease, in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. More detailed analysis of disease activity is required to further explain the associations of the markers described above with disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12805","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T11:32:45Z","timestamp":1448969565000},"page":"1078-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Overlooked hematological markers of disease activity in rheumatoid arthritis"],"prefix":"10.1111","volume":"19","author":[{"given":"\u0130brahim","family":"Tekeo\u011flu","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Division of Rheumatology Faculty of Medicine Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6n\u00fcl","family":"G\u00fcrol","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology 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