{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:13:54Z","timestamp":1789528434943,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to compare the efficacy of tocilizumab, rituximab and abatacept after a non\u2010tumor necrosis factor inhibitor (non\u2010TNFi) failure for the treatment of rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This retrospective multi\u2010centre study included patients treated for RA with abatacept, rituximab or tocilizumab after having received in the previous line the first non\u2010TNFi. Data were collected from patient charts. The primary endpoint was the delta Disease Activity Index of 28 joints \u2013 erythrocyte sedimentation rate (DAS28\u2010ESR) and DAS28\u2010CRP (C\u2010reactive protein) at 12 months. The relative change in primary outcome measures from baseline were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred patients started a second non\u2010TNFi between 2006 and 2013, including 15 patients treated with rituximab, 36 with tocilizumab and 49 with abatacept. The change of DAS28\u2010ESR was significantly different between the three groups (<jats:italic>P<\/jats:italic> = 0.001). In <jats:italic>post hoc<\/jats:italic> pairwise comparisons, patients treated with tocilizumab had a higher decrease of the DAS28\u2010ESR than patients treated by abatacept (median [interquartile range: IQR]: 36% [0; 54%] <jats:italic>vs<\/jats:italic>. 0% [0; 20%], <jats:italic>P<\/jats:italic> = 0.002). A similar non\u2010significant difference was found between tocilizumab and rituximab (median [IQR] decrease: 36% [0; 54%] <jats:italic>vs<\/jats:italic>. 0% [\u221211; 34%], <jats:italic>P<\/jats:italic> = 0.07). Similar results were found with the 12 months change in DAS28\u2010CRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests a better efficacy of tocilizumab compared with abatacept and rituximab in situations of non\u2010TNFi failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12845","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T04:52:56Z","timestamp":1459140776000},"page":"1093-1102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparative efficacy of tocilizumab, abatacept and rituximab after non\u2010TNF inhibitor failure: results from a multicentre study"],"prefix":"10.1111","volume":"19","author":[{"given":"Tristan","family":"Pascart","sequence":"first","affiliation":[{"name":"Department of Rheumatology Saint\u2010Philibert Hospital, Lille University Lomme France"},{"name":"Department of Rheumatology CHU Lille Lille France"},{"name":"EA 4490 University\u2010Hospital of Lille CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Philippe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Drumez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Univ. Lille CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Deprez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Valenciennes Hospital Valenciennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cortet","sequence":"additional","affiliation":[{"name":"Department of Rheumatology CHU Lille Lille France"},{"name":"EA 4490 University\u2010Hospital of Lille CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Duhamel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Univ. Lille CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Houvenagel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Saint\u2010Philibert Hospital, Lille University Lomme France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9\u2010Marc","family":"Flipo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126532"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22025"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.074773"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105197"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092932"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204573"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.05.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201324"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203993"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu158"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204417"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.084459"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.613638"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.02.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008794.pub2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)81056-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-155846"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60250-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37711"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204577"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007848"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111345"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.12.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140129"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0630-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.091876"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12845","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:34:43Z","timestamp":1696516483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,27]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/1756-185X.12845"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12845","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,27]]},"assertion":[{"value":"2016-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}