{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:19:48Z","timestamp":1790813988509,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chonnam National University Hospital Biomedical Research Institute","award":["CRI13904-24.3"],"award-info":[{"award-number":["CRI13904-24.3"]}]},{"name":"Bitgoeul Chonnam National University Hospital"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cardiac autonomic dysfunction (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) is frequently found in patients with fibromyalgia (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>). Thus, we evaluated whether heart rate variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>) is superior to the Ewing tests in detecting <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 35 females with <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> and 25 age\u2010matched healthy females. In Ewing tests, results were added to yield an overall score. An abnormal result on deep breathing, the Valsalva maneuver, or orthostatic standing was counted as 1 point. A change in systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) of &gt; 10 mmHg while standing counted as 1 point, and a change of &gt; 20 mmHg as 2 points. A score of 0 was regarded as no <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>, a score of \u2265 2 as severe <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> and a score of 1 as mild <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> was measured in two ways: by R\u2010R intervals (time\u2010domain analysis) and by spectral analysis of a series of successive R\u2010R intervals (frequency\u2010domain analysis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> patients had significantly lower expiratory\/inspiratory (E\/I) ratios, lower Valsalva ratios and higher <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> values than healthy controls (<jats:italic>P<\/jats:italic> &lt; 0.05, <jats:italic>P<\/jats:italic> &lt; 0.05, <jats:italic>P<\/jats:italic> &lt; 0.01, respectively). In the frequency domain, very low\u2010frequency and low\u2010frequency bands were also lower in <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> patients than controls (both <jats:italic>P<\/jats:italic> &lt; 0.05). Based on the discriminant analysis of the Ewing tests, 54.4% of cases were correctly classified. The addition of <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> parameters did not improve the reclassification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> does not improve detection of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> patients over classic autonomic testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12858","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T11:06:43Z","timestamp":1462014403000},"page":"804-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of heart rate variability and classic autonomic testing for detection of cardiac autonomic dysfunction in patients with 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