{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:43:49Z","timestamp":1695973429380},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gout is a clinical syndrome that occurs as an inflammatory response to increased concentration of uric acid and monosodium urate crystals. Familial Mediterranean fever (<jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>) is a hereditary autoinflammatory disease with autosomal recessive inheritance. The <jats:italic>Mediterranean fever<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content><\/jats:italic>) gene is responsible for <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> and encodes pyrin that suppresses the inflammatory response. Most of the <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>\u2010related mutations have been identified in exon 2 (e.g., E148Q and R202Q) and exon 10 (M680I, M694V, M694I and V726A) of the <jats:italic><jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content><\/jats:italic> gene, and each missense mutation is known to increase production of interleukin\u20101, a proinflammatory cytokine. Our aim was to investigate effects of <jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content> variant alleles on the manifestations of gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one patients diagnosed with gout (age: 61.73 \u00b1 11.73 years, F\/M: 14\/57) and 50 healthy subjects (age: 61.48 \u00b1 11.97, F\/M: 10\/40) as controls were included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content><\/jats:italic> variant alleles were found in 24 (33.8%) of the gout patients and in 13 (26%) of the control subjects; the difference was not statistically significant. In the gout patients with a <jats:italic><jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content><\/jats:italic> variant allele, the interval between the first two attacks was shorter (<jats:italic>P<\/jats:italic> = 0.014), and the platelet count was higher (<jats:italic>P<\/jats:italic> = 0.026), compared to the patients without a variant allele. In addition, the patients with a <jats:italic><jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content><\/jats:italic> variant allele showed the higher incidence of tophus (8.5% <jats:italic>vs<\/jats:italic>. 1.4%) (<jats:italic>P<\/jats:italic> = 0.005) and the higher number of attacks per year (<jats:italic>P<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose that a variant allele of the <jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content> gene may be responsible for the severity of gout.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12872","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T13:37:44Z","timestamp":1462023464000},"page":"338-346","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A variant allele of the Mediterranean\u2010fever gene increases the severity of gout"],"prefix":"10.1111","volume":"21","author":[{"given":"Ayse","family":"Balkarli","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Antalya Training and Research Hospital Konyaalt\u0131 Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Tepeli","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Pamukkale University Hospital K\u0131n\u0131kl\u0131 Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Balkarli","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology Akdeniz University Hospital Konyaalt\u0131 Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif","family":"Kaya","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Pamukkale University Hospital K\u0131n\u0131kl\u0131 Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli","family":"Cobankara","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Pamukkale University Hospital K\u0131n\u0131kl\u0131 Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2014.03.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24458"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.10.3223"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07733.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200009)16:3<271::AID-HUMU16>3.0.CO;2-A"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363967"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei279"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27683"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.08.006"},{"key":"e_1_2_6_11_1","first-page":"640","article-title":"Uric acid: friend or foe? 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