{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:42:42Z","timestamp":1726760562846},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor, and Welfare of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to assess 5\u2010year changes in physical function and factors associated with improvement among patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) in daily clinical practice, focusing on the effect of treatments, including biologic agents, in the early stage of disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Database of Rheumatic Diseases by <jats:styled-content style=\"fixed-case\">iR<\/jats:styled-content>\u2010net in Japan (<jats:italic>NinJa<\/jats:italic>) was searched for patients with disease duration \u2264 2 years and modified health assessment questionnaire (<jats:styled-content style=\"fixed-case\">mHAQ<\/jats:styled-content>) &gt; 0 between 2004 and 2007, so that 510 patients were included in the final analysis. Multivariate\u2010logistic regression analyses were used to identify predictors of 5\u2010year <jats:styled-content style=\"fixed-case\">mHAQ<\/jats:styled-content> disability score improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median <jats:styled-content style=\"fixed-case\">mHAQ<\/jats:styled-content> score was 0.40 at baseline and decreased to a median 0.17 after 5 years. Seventy\u2010four percent of the patients were treated with methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>) and 25% with biologic agents, with early use of biologic agents (within 2 years of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> onset) increasing over time. Multivariate analyses identified higher baseline Disease Activity Score of 28 joints \u2013 C\u2010reactive protein and early use of <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> (within 1 year of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> onset) and of biologic agents (within 2 years) as significantly associated with improved <jats:styled-content style=\"fixed-case\">mHAQ<\/jats:styled-content>; odds ratios of the early treatment were 1.83 (<jats:italic>P<\/jats:italic> = 0.01) for <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> and 2.23 (<jats:italic>P<\/jats:italic> = 0.04) for biologic agents, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Five\u2010year <jats:styled-content style=\"fixed-case\">mHAQ<\/jats:styled-content> improved in early <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients in the <jats:italic>NinJa<\/jats:italic> database. In daily clinical management of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, likewise in clinical trials, early administration of <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> or biologic agents is able to improve physical function outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12877","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T13:49:34Z","timestamp":1462024174000},"page":"828-835","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of early treatment on physical function in daily management of rheumatoid arthritis: a 5\u2010year longitudinal study of rheumatoid arthritis patients in the National Database of Rheumatic Diseases in Japan"],"prefix":"10.1111","volume":"21","author":[{"given":"Akie","family":"Hirata","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Rheumatology 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